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MRI Characterization of Myocardial Tissue in Patients with Fabry's Disease

¹ Department of Radiology, University Federico II, Via Pansini 5, Via Posillipo 196, Napoli 80123, Italy.
² Department of Clinical Medicine and Cardiovascular Sciences, University Federico II, Napoli, Italy.
³ Department of Nephrology, University Federico II, Napoli, Italy.
⁴ Institute of Biostructure and Bioimaging, University Federico II, Napoli, Italy.

OBJECTIVE. Fabry's disease is a multisystem X-linked disorder of lysosomal metabolism frequently associated with left ventricular (LV) hypertrophy. In this study, we aimed to assess whether myocardial T2 relaxation time determined by a black blood multiecho multishot MRI sequence could be used to evaluate cardiac involvement in patients with Fabry's disease.

CONCLUSION. Myocardial T2 relaxation time is prolonged in patients with Fabry's disease compared with that of hypertrophic patients and healthy control subjects. MRI may be useful for the characterization of myocardial tissue in patients with Fabry's disease.

Keywords: cardiac imaging • cardiovascular disease • cerebrovascular disease • Fabry's disease • MRI • renal disease • T2 relaxation time

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