HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Koh, D.-M. Articles by Husband, J. E. Search for Related Content PubMed PubMed Citation Articles by Koh, D.-M. Articles by Husband, J. E. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Predicting Response of Colorectal Hepatic Metastasis: Value of Pretreatment Apparent Diffusion Coefficients

¹ Academic Department of Radiology, Royal Marsden Hospital, Downs Rd., Sutton, Surrey, United Kingdom, SM2 5PT.
² Royal Marsden Hospital, Institute of Cancer Research, Sutton, Surrey, United Kingdom, SM2 5NG.

OBJECTIVE. The purposes of this study were to determine whether the pretreatment apparent diffusion coefficients (ADCs) of hepatic metastatic lesions from colorectal cancer are predictive of response to chemotherapy and to compare the ADCs of metastatic lesions before and after chemotherapy.

SUBJECTS AND METHODS. Twenty patients with potentially operable hepatic lesions larger than 1 cm in diameter metastatic from colorectal carcinoma were prospectively evaluated with diffusion-weighted imaging at three b values before and after chemotherapy. Quantitative ADC maps were calculated with images with b values of 0, 150, and 500 s/mm² (ADC0-500) and with images with b values of 150 and 500 s/mm² (ADC150-500). Regions of interest were drawn around metastatic lesions and randomly over liver. The mean ADC0-500 and mean ADC150-500 of metastatic lesions before and after chemotherapy were compared according to response defined by Response Evaluation Criteria in Solid Tumors criteria.

RESULTS. Twenty-five responding and 15 nonresponding metastatic lesions were evaluated. Nonresponding lesions had a significantly higher pretreatment mean ADC0-500 and mean ADC150-500 than did responding lesions (Mann-Whitney U test, p < 0.002). There was a linear regression relation (r² = 0.34, p = 0.02) between percentage size reduction of metastatic lesions and pretreatment mean ADC150-500. After chemotherapy, responding lesions had a significant increase in mean ADC0-500 and ADC150-500 (Wilcoxon's signed rank, p = 0.025). No significant change was observed in nonresponding metastatic lesions (Wilcoxon's signed rank, p > 0.5) or in normal liver parenchyma (Wilcoxon's signed rank, p >0.4).

CONCLUSION. High pretreatment mean ADC0-500 and mean ADC150-500 of colorectal hepatic metastatic lesions were predictive of poor response to chemotherapy. A significant increase in mean ADC0-500 and ADC150-500 was observed in metastatic lesions that responded to chemotherapy. These findings may have implications for development of individualized therapy.

Keywords: abdominal imaging • apparent diffusion coefficient • cancer • diffusion-weighted imaging • liver • MRI

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				C. Schraml, N. F. Schwenzer, P. Martirosian, M. Bitzer, U. Lauer, C. D. Claussen, and M. Horger Diffusion-Weighted MRI of Advanced Hepatocellular Carcinoma During Sorafenib Treatment: Initial Results Am. J. Roentgenol., October 1, 2009; 193(4): W301 - W307. [Abstract] [Full Text] [PDF]

				A. Qayyum Diffusion-weighted Imaging in the Abdomen and Pelvis: Concepts and Applications RadioGraphics, October 1, 2009; 29(6): 1797 - 1810. [Abstract] [Full Text] [PDF]

				R. N. Low, C. P. Sebrechts, R. M. Barone, and W. Muller Diffusion-Weighted MRI of Peritoneal Tumors: Comparison With Conventional MRI and Surgical and Histopathologic Findings--A Feasibility Study Am. J. Roentgenol., August 1, 2009; 193(2): 461 - 470. [Abstract] [Full Text] [PDF]

				H. Kandpal, R. Sharma, K. S. Madhusudhan, and K. S. Kapoor Respiratory-Triggered Versus Breath-Hold Diffusion-Weighted MRI of Liver Lesions: Comparison of Image Quality and Apparent Diffusion Coefficient Values Am. J. Roentgenol., April 1, 2009; 192(4): 915 - 922. [Abstract] [Full Text] [PDF]

				A. C. Braithwaite, B. M. Dale, D. T. Boll, and E. M. Merkle Short- and Midterm Reproducibility of Apparent Diffusion Coefficient Measurements at 3.0-T Diffusion-weighted Imaging of the Abdomen Radiology, February 1, 2009; 250(2): 459 - 465. [Abstract] [Full Text] [PDF]

				T NIWA, M UENO, S OHKAWA, T YOSHIDA, T DOIUCHI, K ITO, and T INOUE Advanced pancreatic cancer: the use of the apparent diffusion coefficient to predict response to chemotherapy Br. J. Radiol., January 1, 2009; 82(973): 28 - 34. [Abstract] [Full Text] [PDF]

				D. C. Sullivan Anatomic and Functional Imaging Techniques for Response Assessment in Oncology ASCO Educational Book, January 1, 2009; 2009(1): 119 - 122. [Abstract] [Full Text] [PDF]

				H. Kim, D. E. Morgan, D. J. Buchsbaum, H. Zeng, W. E. Grizzle, J. M. Warram, C. R. Stockard, L. R. McNally, J. W. Long, J. C. Sellers, et al. Early Therapy Evaluation of Combined Anti-Death Receptor 5 Antibody and Gemcitabine in Orthotopic Pancreatic Tumor Xenografts by Diffusion-Weighted Magnetic Resonance Imaging Cancer Res., October 15, 2008; 68(20): 8369 - 8376. [Abstract] [Full Text] [PDF]

				Y. Cui, X.-P. Zhang, Y.-S. Sun, L. Tang, and L. Shen Apparent Diffusion Coefficient: Potential Imaging Biomarker for Prediction and Early Detection of Response to Chemotherapy in Hepatic Metastases Radiology, September 1, 2008; 248(3): 894 - 900. [Abstract] [Full Text] [PDF]