HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Kodama, Y. Articles by Charnsangavej, C. Search for Related Content PubMed PubMed Citation Articles by Kodama, Y. Articles by Charnsangavej, C. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Comparison of CT Methods for Determining the Fat Content of the Liver

¹ Department of Diagnostic Radiology, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Box 368, Houston TX 77030.
² Department of Pathology, The University of Texas M. D. Anderson Cancer Center, Houston TX.
³ Department of Biostatistics and Applied Mathematics, University of Texas M. D. Anderson Cancer Center, Houston TX.
⁴ Department of Surgical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston TX.

OBJECTIVE. The purpose of this study was to assess which of a number of methods of measuring attenuation on CT scans is best for prediction of hepatic fat content.

MATERIALS AND METHODS. This retrospective study was approved by our institutional review board. Consecutively registered patients who underwent liver resection for metastatic disease formed the study group. Attenuation measurements were obtained from 12 regions of interest in the liver and three in the spleen on both unenhanced and portal phase contrast-enhanced preoperative hepatic CT images. Hepatic attenuation measurements were analyzed both with and without normalization with the spleen. Normalization included both differences and ratios between hepatic and splenic attenuation values. Pathologic fat content was graded semiquantitatively as a percentage of the nonneoplastic liver parenchyma of the resected specimen. Average attenuation values of the liver were compared with pathologic fat content, as were the differences and ratios between hepatic and splenic attenuation values. Linear regression analysis was conducted on a log-log scale.

RESULTS. Data on 88 patients were analyzed. On unenhanced and contrast-enhanced CT images, all associations between pathologic fat content and attenuation measurements were significant (p < 0.0001). All series of R² values for unenhanced CT scans were much higher than those for contrast-enhanced CT scans. The R² values of liver-only measurement were higher than those of hepatic values normalized with splenic values on both unenhanced (0.646-0.649 > 0.523, 0.565) and contrast-enhanced (0.516 > 0.242, 0.344) CT.

CONCLUSION. Measurement of attenuation of liver only on unenhanced CT scans is best for prediction of pathologic fat content.

Keywords: CT • fat measurement • liver disease

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				X. Ma, N.-S. Holalkere, A. K. R, M. Mino-Kenudson, P. F. Hahn, and D. V. Sahani Imaging-based Quantification of Hepatic Fat: Methods and Clinical Applications RadioGraphics, September 1, 2009; 29(5): 1253 - 1277. [Abstract] [Full Text] [PDF]

				M. E. Tushuizen, M. C. Bunck, P. J. Pouwels, and M. Diamant Pancreatic Fat Content and {beta}-Cell Function in Men With and Without Type 2 Diabetes: Response to Saisho, Butler, and Butler Diabetes Care, May 1, 2008; 31(5): e39 - e39. [Full Text] [PDF]

				S. B. Reeder, F. Ranallo, and A. J. Taylor CT and MRI for Determining Hepatic Fat Content Am. J. Roentgenol., February 1, 2008; 190(2): W167 - W167. [Full Text] [PDF]