HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Fayad, L. M. Articles by Bluemke, D. A. Search for Related Content PubMed PubMed Citation Articles by Fayad, L. M. Articles by Bluemke, D. A. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Characterization of Musculoskeletal Lesions on 3-T Proton MR Spectroscopy

¹ Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine and Johns Hopkins Medical Institutions, 601 N Caroline St., JHOC 3171C, Baltimore, MD 21287.
² Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD.
³ Division of MR Research, Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD.
⁴ Department of Radiology, Health Science Informatics, Johns Hopkins University School of Medicine, Baltimore, MD.
⁵ Division of Orthopaedics and Oncology, Department of Orthopaedic Surgery, Johns Hopkins Medical Institutions, Baltimore, MD.
⁶ Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD.
⁷ MRI Division, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, MD.

OBJECTIVE. The purpose of our study was to determine the feasibility and value of proton MR spectroscopy at 3 T for characterizing musculoskeletal tumors.

SUBJECTS AND METHODS. At 3 T, 18 patients with musculoskeletal lesions (four histologically proven to be malignant, 14 proven benign histologically or at clinical follow-up) underwent 23 MR spectroscopy studies, 20 with a single-voxel technique and three with a multivoxel technique. Seventeen patients were imaged with a surface coil and six with a body coil. Choline signal (3.2 ppm) was measured in each voxel and expressed relative to background noise as signal-to-noise ratio (SNR). Choline SNRs of malignant tumors and benign lesions were compared.

RESULTS. Diagnostic spectra were obtained in 20 of 23 lesions. For malignant lesions (osteosarcoma with two MR spectroscopy sites, metastasis, grade 1 sarcoma), choline SNRs were 5.2 and 4.2 (performed with body coil) and 4.8 and 18.7 (performed with surface coil), respectively. For benign lesions (neurofibroma, two stress reactions, bone cyst, hemangioma, lipoma, Baker cyst), choline SNR was 6.3 (with surface coil), 5.5 (with surface coil), and not detected for five cases. Seven postoperative patients with myocutaneous flaps showed either the typical spectrum of muscle or negligible choline. Only a water peak existed in a bone cyst and a significant lipid peak in a lipoma. Choline SNRs were different for malignant and benign lesions (11.7 vs 2.3, p = 0.04, as performed with a surface coil).

CONCLUSION. At 3 T, both single-voxel and multivoxel MR spectroscopy are feasible. Proton MR spectroscopy is a potential noninvasive tool for characterizing lesion composition and malignant activity.

Keywords: bone • MRI • MR spectroscopy • MR technique • oncologic imaging • soft-tissue neoplasms

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				P. L. Sah, R. Sharma, H. Kandpal, A. Seith, S. Rastogi, S. Bandhu, and N. R. Jagannathan In Vivo Proton Spectroscopy of Giant Cell Tumor of the Bone Am. J. Roentgenol., February 1, 2008; 190(2): W133 - W139. [Abstract] [Full Text] [PDF]