AJR ARRS Member Benefits
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Tsai, I-C.
Right arrow Articles by Ting, H.-J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Tsai, I-C.
Right arrow Articles by Ting, H.-J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
DOI:10.2214/AJR.07.2541
AJR 2008; 190:W47-W53
© American Roentgen Ray Society

Original Research

Contrast Enhancement in Cardiac MDCT: Comparison of Iodixanol 320 Versus Iohexol 350

I-Chen Tsai1,2,3,4, Tain Lee1,2,3, Wei-Lin Tsai1,2,3,4, Min-Chi Chen1, Ming-Ju Wu4,5, Wen-Lieng Lee3,4,6 and Hui-Ju Ting7

1 Department of Radiology, 407, Taichung Veterans General Hospital, No. 160, Section 3, Taichung Harbor Rd., Taichung, Taiwan, ROC.
2 Faculty of Medicine, Medical College of Chung Shan Medical University, Taiwan, ROC.
3 Department of Medicine, National Yang Ming University, Taiwan, ROC.
4 Institute of Clinical Medicine, National Yang Ming University, Taiwan, ROC.
5 Department of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
6 Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan, ROC.
7 Department of Applied Foreign Languages, Overseas Chinese Institute of Technology, Taiwan, ROC.

OBJECTIVE. The objective of our study was to evaluate whether iodixanol 320 mg I/mL (iodixanol 320), with the highest iodine concentration of dimeric nonionic contrast agents on the market, results in decreased vascular or myocardial enhancement compared with iohexol 350 mg I/mL (iohexol 350).

SUBJECTS AND METHODS. During a 4-month period, 72 patients referred for cardiac MDCT were consecutively enrolled and randomized into two groups: iohexol 350 and iodixanol 320. The injection and scanning protocols were the same for both groups. Enhancement of the right heart, left heart, coronary arteries, and left ventricular (LV) myocardium in both the arterial and delayed phases was compared using two-tailed independent Student's t test.

RESULTS. Enhancement in the right heart, left heart, coronary arteries, and LV myocardium in the arterial phase showed no statistical difference (p > 0.05) between the two groups, although the iohexol group showed slightly higher enhancement (average, 11.2 H) in all of the areas. Surprisingly, in the delayed phase, the iodixanol group displayed significantly higher (7.7 H) persistent enhancement (p < 0.05) in the LV myocardium.

CONCLUSION. Iodixanol 320 can provide vascular enhancement in cardiac MDCT that is similar to iohexol 350. In the delayed phase, iodixanol 320 shows significantly higher delayed enhancement (7.7 H) in the LV myocardium than iohexol 350.

Keywords: cardiac imaging • contrast media • coronary arteries • CT coronary angiography • heart disease • hemodynamics • MDCT • myocardium


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2008 by the American Roentgen Ray Society.