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DOI:10.2214/AJR.07.2610
AJR 2008; 190:W234-W236
© American Roentgen Ray Society

Technical Innovation

Microcalcifications of Breast Tissue: Appearance on Synchrotron Radiation Imaging with 6-µm Resolution

Keiko Imamura1, Norishige Ehara1, Yoichi Inada2, Yoshihide Kanemaki1, Joji Okamoto3, Ichiro Maeda4, Keiko Miyamoto3, Haruki Ogata3, Hisanori Kawamoto3, Yasuo Nakajima1, Mamoru Fukuda3, Keiji Umetani5 and Kentarou Uesugi5

1 Department of Radiology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ward, Kawasaki, Kanagawa 216-8511, Japan.
2 Department of Physics, St. Marianna University School of Medicine, Kawasaki, Japan.
3 Department of Breast Surgery, St. Marianna University School of Medicine, Kawasaki, Japan.
4 Department of Pathology, St. Marianna University School of Medicine, Kawasaki, Japan.
5 Japan Synchrotron Radiation Research Institute, Kouto, Hyogo 679-5198, Japan.

OBJECTIVE. The purpose of this study was to use synchrotron radiation imaging with 6-µm resolution to evaluate amorphous and pleomorphic breast tissue microcalcifications.

CONCLUSION. Synchrotron radiation imaging depicted microcalcifications as small as 24 µm. Imaging with this technique revealed that most amorphous and pleomorphic calcifications on conventional mammograms are clusters of fine specks and that in addition to the shape or density of a speck, the distribution density of clustered specks is a factor determining the apparent shape.

Keywords: breast imaging • mammogram • microcalcification • morphology • synchrotron radiation imaging


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