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Measuring Noncalcified Coronary Atherosclerotic Plaque Using Voxel Analysis with MDCT Angiography: Phantom Validation

¹ Department of Radiology, Beth Israel Deaconess Medical Center/Harvard Medical School, One Deaconess Rd., WCC-302, Boston, MA 02215.
² PERFUSE Core Laboratory and Data Coordinating Center, Harvard Medical School, Boston, MA.
³ Small Animal Imaging Facility, Harvard Medical School, Boston, MA.

OBJECTIVE. This purpose of this study was to evaluate the accuracy and reproducibility of a voxel analysis technique for measuring noncalcified plaque in the coronary arteries.

MATERIALS AND METHODS. Polyethylene phantoms representing noncalcified plaque were scanned in both MDCT and micro-CT scanners and inter- and intrareader variability of volume calculation was performed.

RESULTS. Volume measurements by both MDCT and micro-CT were comparable to the true volume as measured by micrometry (< 3%, p = 0.05).

CONCLUSION. There appears to be no significant difference (< 3%) between MDCT and micro-CT measurements.

Keywords: aorta • CT angiography • coronary imaging • MDCT • micro-CT • voxel analysis