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Assessment of Global Right Ventricular Function on 64-MDCT Compared with MRI

¹ Department of Diagnostic Radiology, RWTH Aachen University Hospital, Pauwelsstraβe 30, D 52057 Aachen, Germany.
² Department of Cardiology, Sarawak General Hospital, Sarawak, Malaysia.
³ Siemens Medical Solutions, Erlangen, Germany.

OBJECTIVE. The aim of this study was to compare ECG-gated 64-MDCT with MRI for the assessment of global right ventricular (RV) function from coronary CT angiography data.

SUBJECTS AND METHODS. Thirty-eight patients (25 men, 13 women; mean age ± SD, 55.0 ± 8.8 years) with suspected coronary artery disease underwent contrast-enhanced 64-MDCT (64 x 0.6 mm, 120 kV, 770 mAs_eff) and 1.5-T MRI (balanced fast-field echo; TR/TE, 3.3/1.6; flip angle, 60°; 50 phases). Double oblique short-axis MDCT and MR images were used for further analysis. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were computed from manually drawn endocardial contours of the right ventricle. For statistical analysis, repeated-measures analysis of variance and Pearson's correlation coefficients were calculated. Bland-Altman plots were computed.

RESULTS. In general, RV volumes calculated from 64-MDCT agreed well with those calculated from MRI. The mean EF (± SD) calculated from MDCT and MRI was 51.0% ± 7.8% and 51.4% ± 7.3%, respectively. An excellent correlation was observed for EDV (r = 0.99), ESV (r = 0.98), SV (r = 0.98), and EF (r = 0.97). Bland-Altman plots showed no systematic variation between MDCT and MRI data. No statistically significant differences (p 0.05) between the techniques were found.

CONCLUSION. Although contrast injection is optimized for visualization of the coronary arteries, retrospectively ECG-gated 64-MDCT permits reliable assessment of global RV function.

Keywords: cardiac imaging • heart disease • MDCT • MRI • right ventricular function

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