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DOI:10.2214/AJR.07.3022
AJR 2008; 190:1358-1361
© American Roentgen Ray Society

Original Research

Assessment of Global Right Ventricular Function on 64-MDCT Compared with MRI

Cédric Plumhans1, Georg Mühlenbruch1, Annuar Rapaee2, Kui-Hian Sim2, Tobias Seyfarth3, Rolf W. Günther1 and Andreas H. Mahnken1

1 Department of Diagnostic Radiology, RWTH Aachen University Hospital, Pauwelsstraβe 30, D 52057 Aachen, Germany.
2 Department of Cardiology, Sarawak General Hospital, Sarawak, Malaysia.
3 Siemens Medical Solutions, Erlangen, Germany.

OBJECTIVE. The aim of this study was to compare ECG-gated 64-MDCT with MRI for the assessment of global right ventricular (RV) function from coronary CT angiography data.

SUBJECTS AND METHODS. Thirty-eight patients (25 men, 13 women; mean age ± SD, 55.0 ± 8.8 years) with suspected coronary artery disease underwent contrast-enhanced 64-MDCT (64 x 0.6 mm, 120 kV, 770 mAseff) and 1.5-T MRI (balanced fast-field echo; TR/TE, 3.3/1.6; flip angle, 60°; 50 phases). Double oblique short-axis MDCT and MR images were used for further analysis. End-diastolic volume (EDV), end-systolic volume (ESV), stroke volume (SV), and ejection fraction (EF) were computed from manually drawn endocardial contours of the right ventricle. For statistical analysis, repeated-measures analysis of variance and Pearson's correlation coefficients were calculated. Bland-Altman plots were computed.

RESULTS. In general, RV volumes calculated from 64-MDCT agreed well with those calculated from MRI. The mean EF (± SD) calculated from MDCT and MRI was 51.0% ± 7.8% and 51.4% ± 7.3%, respectively. An excellent correlation was observed for EDV (r = 0.99), ESV (r = 0.98), SV (r = 0.98), and EF (r = 0.97). Bland-Altman plots showed no systematic variation between MDCT and MRI data. No statistically significant differences (p ≤ 0.05) between the techniques were found.

CONCLUSION. Although contrast injection is optimized for visualization of the coronary arteries, retrospectively ECG-gated 64-MDCT permits reliable assessment of global RV function.

Keywords: cardiac imaging • heart disease • MDCT • MRI • right ventricular function






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