HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Park, Y. Articles by Lee, W. J. Search for Related Content PubMed PubMed Citation Articles by Park, Y. Articles by Lee, W. J. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Growth Rate of New Hepatocellular Carcinoma After Percutaneous Radiofrequency Ablation: Evaluation with Multiphase CT

¹ All authors: Department of Radiology and Center for Imaging Science, Samsung Medical Center, Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul 135-710, Republic of Korea.

OBJECTIVE. The purpose of this study was to evaluate with serial follow-up CT examinations the growth rate of new hepatocellular carcinoma (HCC) developing after percutaneous radiofrequency ablation and to determine an appropriate follow-up interval for imaging.

MATERIALS AND METHODS. Sixty-two new HCCs appearing after percutaneous radiofrequency ablation in 59 patients who underwent follow-up multiphase CT were retrospectively identified. The volume of the new HCCs at follow-up CT was measured on a PACS monitor with an area measuring tool and summation-of-areas technique. We calculated tumor volume doubling time and tumor diameter doubling time. The growth rate was represented by tumor volume doubling time. We also used stepwise multiple linear regression analysis to evaluate the relation between clinical variables and tumor volume doubling time.

RESULTS. Mean baseline and follow-up tumor volumes were 580 mm³ (range, 85–13,861 mm³) and 2,072 mm³ (range, 535–35,937 mm³). Mean baseline and follow-up tumor diameters were 9.9 mm (range, 5.5–29.8 mm) and 15.0 mm (range, 10.1–40.9 mm). Mean tumor volume and tumor diameter doubling times were 75 days (range, 21–209 days) and 219 days (range, 57–897 days). Volume doubling times of baseline tumors with a diameter of 1 cm or less were significantly shorter than those of the larger baseline tumors (mean, 55 vs 88 days; p = 0.024).

CONCLUSION. The growth rate of new HCCs after percutaneous radiofrequency ablation was higher than that reported in natural outcome studies of untreated HCCs. The results of our study suggest that a shorter follow-up interval for imaging, 2.5 months (75 days), is appropriate.

Keywords: helical CT • hepatocellular carcinoma • radiofrequency ablation

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				J.-S. Yu, K. W. Kim, D. G. Mitchell, D. Choi, S. K. Verma, D. Bergin, H.-W. L. Hann, and S. K. Herrine Hepatocellular Carcinoma: Progression in Patients with Hepatitis B versus C Virus Infection Radiology, December 1, 2008; 249(3): 1082 - 1083. [Full Text] [PDF]