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DOI:10.2214/AJR.07.2467
AJR 2008; 191:285-289
© American Roentgen Ray Society

Clinical Observations

Chemoembolization of Hepatic Metastases from Ocular Melanoma: Assessment of Response with Contrast-Enhanced and Diffusion-Weighted MRI

Manon Buijs1, Josephina A. Vossen, Kelvin Hong, Christos S. Georgiades, Jean-Francois H. Geschwind and Ihab R. Kamel

1 All authors: Russell H. Morgan Department of Radiology and Radiological Sciences, Johns Hopkins Hospital, 601 N Caroline St., Rm. 3235A, Baltimore, MD 21287.

OBJECTIVE. The purpose of this study was to assess the utility of assessment of tumor size and enhancement with diffusion-weighted and conventional MRI in the evaluation of response to transarterial chemoembolization therapy for metastatic ocular melanoma.

CONCLUSION. In patients with ocular melanoma and liver metastasis treated with transarterial chemoembolization, functional MRI showed significant changes in the lesions. These changes included a decrease in tumor enhancement and an increase in the apparent diffusion coefficient of the tumor, suggesting increasing tumor necrosis and cell death.

Keywords: diffusion-weighted MRI • hepatic metastases • liver • metastatic ocular melanoma • perfusion MRI • transarterial chemoembolization • treatment response


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[Abstract] [Full Text] [PDF]


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