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Multiple Hepatic Adenomas Associated with Liver Steatosis at CT and MRI: A Case-Control Study

¹ Department of Radiology, University of Pittsburgh Medical Center (Presbyterian Campus), Pittsburgh, PA.
² Present address: Instituto di Radiologia, Azienda Ospedaliero-Universitaria "Santa Maria della Misericordia" di Udine, Via Colugna 50, 33100 Udine (UD), Italy.
³ Department of Surgery, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands.
⁴ Department of Pathology, University of Pittsburgh Medical Center, Pittsburgh, PA.

OBJECTIVE. The objective of our study was to investigate the relationship between hepatic adenoma and liver steatosis.

MATERIALS AND METHODS. Radiology and pathology records from January 1999 to March 2007 were reviewed to identify 24 patients (22 women and two men; mean age, 40 years) with a pathology-proven diagnosis of hepatic adenoma (mean size ± SD, 7.2 ± 3.7 cm) who underwent helical contrast-enhanced CT (n = 23) and/or gadolinium-enhanced MRI (n = 8). The control group was composed of 24 patients of similar age and sex (21 women and three men; mean age, 43 years) with hepatic hemangioma who underwent CT or MR evaluation during the same time period. Two radiologists independently interpreted the imaging studies to determine the number of lesions and whether steatosis was present. The difference in prevalence of steatosis between the adenoma group versus the control group and the difference between patients with a single hepatic adenoma versus those with multiple hepatic adenomas were assessed (chi-square test).

RESULTS. Hepatic steatosis was present in 14 of 24 patients (58%) with hepatic adenoma versus seven of 24 patients (29%) with hemangioma (p = 0.042). Steatosis was more common in patients with multiple hepatic adenomas (9/11, 82%) than in those with a single hepatic adenoma (5/13, 38%) (p = 0.047).

CONCLUSION. Hepatic adenomas occur more frequently and more often are multiple in patients with hepatic steatosis.

Keywords: CT • hepatic adenomas • hepatic adenomatosis • liver adenomas • liver adenomatosis • liver steatosis • MRI

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