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DOI:10.2214/AJR.08.1114
AJR 2008; 191:W299-W306
© American Roentgen Ray Society

Review

Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): Imaging Manifestations in the Head and Neck

Donald V. La Barge, III1, Karen L. Salzman1, H. Ric Harnsberger1, Lawrence E. Ginsberg2, Bronwyn E. Hamilton1,3, Richard H. Wiggins, III1 and Patricia A. Hudgins4

1 Department of Radiology, University of Utah, 30 N 1900 E, 1A71, Salt Lake City, UT 84132-2140.
2 Department of Diagnostic Imaging, The University of Texas M. D. Anderson Cancer Center, Houston, TX.
3 Department of Diagnostic Radiology, Oregon Health Sciences University, Portland, OR.
4 Department of Radiology, Emory University, Atlanta, GA.

OBJECTIVE. We present the largest case series in the English-language imaging literature, emphasizing the variety of presentations of Rosai-Dorfman disease in the head and neck.

CONCLUSION. Rosai-Dorfman disease is a rare disorder with multiple sites of involvement in the head and neck.

Keywords: emperipolesis • histiocytosis • lymphadenopathy • lymphoma • Rosai-Dorfman disease • sinus


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