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DOI:10.2214/AJR.09.2866
AJR 2009; 193:287-294
© American Roentgen Ray Society


Perspective

Systems Diagnostics: The Systems Approach to Molecular Imaging

Daniel Y. Lee1 and King C. P. Li1,2

1 Department of Radiology, Nuclear Medicine Division, The Methodist Hospital Research Institute, 6565 Fannin St., MB1-066, Houston, TX 77030.
2 Department of Radiology, Weill Cornell Medical College, New York, NY.

Abstract

OBJECTIVE. Molecular imaging has emerged as a powerful technology that has already changed the practice of modern medicine. During this same period, the monumental genome project has sequenced man's entire genetic content. Now the postgenomic aim is to understand the dynamic interactions of the encoded components and their regulatory mechanisms.

CONCLUSION. Molecular imaging is well positioned to play a major role in this massive effort as we move toward a comprehensive paradigm for assessing health and disease.

Keywords: bioinformatics • computational biology • genomics • molecular imaging • systems biology


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