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DOI:10.2214/AJR.09.2687
AJR 2009; 193:W373-W380
© American Roentgen Ray Society

Pictorial Essay

Spectrum of Imaging Findings in Immunocompromised Patients With HHV-6 Infection

Alexander Sauter1, Ulrike Ernemann2, Robert Beck3, Karin Klingel4, Heiko Mahrholdt5, Michael Bitzer6 and Marius Horger1

1 Department of Diagnostic Radiology, Eberhard-Karls-University, Hoppe-Seyler-Str. 3, 72076 Tuebingen, Germany.
2 Department of Diagnostic Neuroradiology, Eberhard-Karls-University, Tuebingen, Germany.
3 Institute of Medical Virology, Eberhard-Karls-University, Tuebingen, Germany.
4 Department of Molecular Pathology, Eberhard-Karls-University, Tuebingen, Germany.
5 Division of Cardiology, Robert-Bosch Medical Center, Stuttgart, Germany.
6 Department of Gastroenterology and Hepatology, Eberhard-Karls-University, Tuebingen, Germany.

OBJECTIVE. The aim of this article is to review systemic manifestations of human herpes virus 6 (HHV-6) associated diseases in immunocompromised patients.

CONCLUSION. The spectrum of HHV-6 associated disorders is broad, but radiologists are frequently not familiar with these disorders. In the clinical setting of acute infection in an immunocompromised patient, the presence of one of these findings (e.g., limbic encephalitis; atypical interstitial pneumonia; pericarditis or myocarditis; or, less commonly, gastrointestinal or hepatobiliary disorders) should raise the suspicion of a possible HHV-6 related complication.

Keywords: colitis • drug reaction with eosinophilia and systemic symptoms (DRESS) • encephalitis • gastroenteritis • human herpes virus 6 (HHV-6) • interstitial pneumonitis • limbic encephalitis • myocarditis


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