HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Figures Only Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Google Scholar Articles by Mollura, D. J. Articles by Bluemke, D. A. PubMed PubMed Citation Articles by Mollura, D. J. Articles by Bluemke, D. A. Social Bookmarking                      What's this? Hotlight (NEW!) What's Hotlight?

Imaging Findings in a Fatal Case of Pandemic Swine-Origin Influenza A (H1N1)

¹ Department of Radiology and Imaging Sciences, National Institutes of Health, Clinical Center, Bethesda, MD.
² Department of Infectious Diseases, Flushing Hospital Medical Center, Flushing, NY.
³ Department of Medicine, Weill Cornell Medical College, New York, NY.
⁴ Department of Emergency Medicine, Flushing Hospital Medical Center, Flushing, NY.
⁵ Department of Critical Care Medicine, Flushing Hospital Medical Center, Flushing, NY.
⁶ Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University, 600 N Wolfe St., Baltimore, MD 21287.
⁷ Integrated Research Facility, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.
⁸ Viral Pathogenesis and Evolution Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Abstract

OBJECTIVE. Although most cases of swine-origin influenza A (H1N1) virus (S-OIV) have been self-limited, fatal cases raise questions about virulence and radiology's role in early detection. We describe the radiographic and CT findings in a fatal S-OIV infection.

CONCLUSION. Radiography showed peripheral lung opacities. CT revealed peripheral ground-glass opacities suggesting peribronchial injury. These imaging findings raised suspicion of S-OIV despite negative H1N1 influenza rapid antigen test results from two nasopharyngeal swabs; subsequently, those results were proven to be false-negatives by reverse transcriptase polymerase chain reaction. This case suggests a role for CT in the early recognition of severe S-OIV.

Keywords: chest CT • emergency medicine • H1N1 • infectious diseases • multifocal ground-glass opacities • swine-origin influenza A

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				H. H. Guo, R. T. Sweeney, D. Regula, and A. N. Leung Best Cases from the AFIP: Fatal 2009 Influenza A (H1N1) Infection, Complicated by Acute Respiratory Distress Syndrome and Pulmonary Interstitial Emphysema RadioGraphics, January 12, 2010; (2010) rg.302095213v1. [Full Text]

				L. H. Ketai Conventional Wisdom: Unconventional Virus Am. J. Roentgenol., December 1, 2009; 193(6): 1486 - 1487. [Full Text] [PDF]