AJR InPractice
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

This Article
Right arrow Figures Only
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrow reprints & permissions
Google Scholar
Right arrow Articles by Lim, R. P.
Right arrow Articles by Taouli, B.
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lim, R. P.
Right arrow Articles by Taouli, B.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Hotlight (NEW!)
Right arrow
What's Hotlight?
DOI:10.2214/AJR.09.3036
AJR 2010; 194:1288-1295
© American Roentgen Ray Society

Original Research

Quantification of Hepatic Iron Deposition in Patients With Liver Disease: Comparison of Chemical Shift Imaging With Single-Echo T2*-Weighted Imaging

Ruth P. Lim1, Keren Tuvia1, Cristina H. Hajdu2, Mariela Losada2, Raavi Gupta2, Tejas Parikh1, James S. Babb1 and Bachir Taouli1,3

1 Department of Radiology, New York University Langone Medical Center, New York, NY.
2 Department of Pathology, New York University Langone Medical Center, New York, NY.
3 Present address: Department of Radiology, Mount Sinai Medical Center, One Gustave Levy Pl., Box 1234, New York, NY 10029.

OBJECTIVE. The purpose of this study was to determine the diagnostic performance of chemical shift imaging, compared with that of single-echo T2*-weighted imaging, for hepatic iron quantification in patients with liver disease, and to examine the confounding effect of steatosis.

MATERIALS AND METHODS. Sixty-three patients who underwent liver MRI and who had concomitant liver histopathologic analysis were retrospectively assessed. Chemical shift imaging and T2*-weighted imaging (n = 49) of the liver were reviewed by two independent observers. An iron index for each sequence (IFe-CSI and IFe-T2*, respectively) was correlated with pathologic iron grade (0–4). Receiver operating characteristic curve analysis was performed to assess the accuracy of both sequences for the diagnosis of iron deposition (grades ≥ 1, ≥ 2, and ≥ 3), and the impact of steatosis on accuracy was evaluated.

RESULTS. Forty-seven (74.6%) patients had hepatic siderosis. There was a significant correlation between both IFe-CSI and IFe-T2* with pathologic iron grade (r = 0.65 and –0.61, respectively; p < 0.0001 for both). IFe-CSI and IFe-T2* were significantly higher or lower in iron grades 2–4 versus grades 0–1 and in grades 3–4 versus grades 0–2 (p < 0.001). Area under the curve values for detecting iron grade ≥ 1, ≥ 2, and ≥ 3 were 0.75, 0.88, and 0.90 for IFe-CSI and 0.72, 0.81, and 0.98 for IFe-T2*. Accuracy was lower for both sequences in steatotic patients for detection of iron grades ≥ 1 and ≥ 2, without reaching significance.

CONCLUSION. Routine chemical shift imaging and single-echo T2*-weighted imaging have excellent diagnostic performance for detection of significant hepatic siderosis (grade ≥ 2). Concomitant steatosis lowers the diagnostic performance of both sequences without reaching significance.

Keywords: chemical shift imaging • iron deposition • liver disease • MRI • steatosis • T2* imaging


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?




HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 2010 by the American Roentgen Ray Society.