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American Journal of Roentgenology, Vol 97, 991-996, Copyright © 1966 by American Roentgen Ray Society

THE EFFECT OF COMBINED RADIATION AND ACTINOMYCIN D THERAPY ON INCOMPLETELY REMOVED MOUSE TUMORS

MELVIN TEFFT M.D.1, BARBARA L. BROWN B.A.1, CHARLOTTE L. MADDOCK M.D.1, and GIULIO J. D'ANGIO M.D.2

1 From The Children's Cancer Research Foundation, The Children's Hospital Medical Center, and Harvard Medical School, Boston, Massachusetts
2 University of Minnesota Hospitals, Minneapolis, Minnesota

In an experimental situation, viz., excised ROS in the AKD2F1 mouse, simulating incomplete surgical removal of tumor, it was shown that roentgen therapy at 1,500 r and actinomycin D at 150 µg./kg., both applied once, very significantly improved

[See table in the PDF file]

the outcome, as compared to surgery alone. Results were measured by two parameters, i.e., survival time and tumor growth rate. When survival times were compared, surgery followed by combined therapy always produced results superior to those obtained by surgery followed by either modality; however, when tumor growth rates were assessed, only in the first experiment were better results obtained, when combined therapy was used after surgery.


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Copyright © 1966 by the American Roentgen Ray Society.