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American Journal of Roentgenology, Vol 99, 453-462, Copyright © 1967 by American Roentgen Ray Society

RADIATION INDUCED HEPATIC INJURY

ITS DETECTION BY SCINTILLATION SCANNING

PHILIP M. JOHNSON M.D.1, FREDERICK M. GROSSMAN M.D.1, and HAROLD L. ATKINS M.D.1

1 From the Division of Nuclear Medicine, Department of Radiology, Columbia University College of Physicians & Surgeons, New York, New York

1. Radiation induced suppression of hepatic reticuloendothelial function was demonstrated by scintillation scanning in 6 patients undergoing therapeutic irradiation of the liver. In the 1 patient so tested, suppressed hepatocellular function was also demonstrated.

2. Evidence of injury to the liver was the de novo appearance of a well defined area of diminished or absent radioactivity on the scintillation scan, corresponding to the position of the radiation portals in each case.

3. In 3 patients, reappearance of normal function was observed 84-106 days post irradiation. Follow-up of the remaining patients was limited to shorter periods.

4. There were no clinical findings attributable to radiation induced hepatic injury.

5. These data are additional evidence that the liver is a relatively radiosensitive organ.


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Copyright © 1967 by the American Roentgen Ray Society.