Creation of Saccular Aneurysms in the Rabbit
A Model Suitable for Testing Endovascular Devices
Talissa A. Altes1,
Harry J. Cloft1,2,
John G. Short1,
Anjob DeGast1,
Huy M. Do1,
Gregory A. Helm3 and
David F. Kallmes1
1
Department of Radiology, University of Virginia Health Services, Box 170,
Charlottesville, VA 22908.
2
Present address: Department of Interventional Neuroradiology and Radiology,
1364 Clifton Rd., N.E., Atlanta, GA 30322.
3
Department of Neurological Surgery, University of Virginia Health Services,
Box 212, Charlottesville, VA 22908.
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Fig. 1. —Diagram of aneurysmal construction shows sheath being introduced
retrograde into mid right common carotid artery (RCC). Balloon catheter is
advanced to origin of right common carotid artery and balloon is inflated.
Elastase is infused into artery. Sheath is removed and vessel tied off. Note
aorta (Ao), right vertebral artery (RV), right subclavian artery (RSC), left
common carotid artery (LCC), vertebral artery (LV) and left subclavian artery
(LSC).
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Fig. 2. —Diagram shows aneurysmal formation from stump of right common
carotid artery. Within 2 weeks of aneuyrism creation, right common carotid
artery stump dilates creating aneurysm (An) arising from apex of curving
vessel, brachiocephalic artery. Note aorta (Ao), right vertebral artery (RV),
right subclavian artery (RSC), left common carotid artery (LCC), vertebral
artery (LV), and left subclavian artery (LSC).
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Fig. 3A. —Aneurysm of 2-weeks' duration in New Zealand white rabbit.
Anteroposterior digital subtraction angiogram with catheter positioned in
aortic arch obtained immediately before sacrifice shows saccular aneurysmal
cavity at former origin of right common carotid artery. Aneurysmal cavity is
approximately 6 mm wide and 8 mm high. Note radiopaque spheres measuring from
2 to 6 mm in diameter. Aneurysmal neck lies along apex of curve of
brachiocephalic and subclavian arteries. Also note right vertebral artery
(curved arrow), left common carotid artery (long straight
arrow), and faint opacification of left subclavian artery (short
straight arrow).
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Fig. 3B. —Aneurysm of 2-weeks' duration in New Zealand white rabbit.
Photomicrograph of histopathologic specimen shows aneurysmal cavity (A),
brachiocephalic artery (long straight arrow), and right subclavian
artery (curved arrow). Small amount of laminated thrombus is seen in
aneurysmal dome (short straight arrow). (H and E, x1)
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Fig. 3C. —Aneurysm of 2-weeks' duration in New Zealand white rabbit.
Photomicrograph of histopathologic specimen stained with van Gieson's stain,
which stains elastic lamina black. Elastic lamina is almost completely
degraded within walls of aneurysmal cavity.
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Fig. 4A. —Aneurysm of 10-weeks' duration in New Zealand white rabbit.
Anteroposterior digital subtraction angiogram with catheter positioned in
aortic arch obtained immediately before sacrifice shows aneurysmal cavity
measuring approximately 5 mm wide and 6 mm high. Radiopaque spheres, ranging
in size from 2 to 5 mm in diameter, are used to measure size of aneurysm.
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Fig. 4B. —Aneurysm of 10-weeks' duration in New Zealand white rabbit.
Photomicrograph of histopathologic specimen shows laminated organizing
thrombus at aneurysmal dome (short straight arrows). Cap of fully
organized thrombus (long straight arrow) is separated from laminated
intraaneurysmal thrombus by neointima (curved arrow). (H and E,
x20)
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Fig. 5A. —Aneurysm of 10-weeks' duration in New Zealand white rabbit.
Anteroposterior IV digital subtraction angiogram obtained 2 weeks after
aneurysm creation. Aneurysmal cavity measures approximately 5 mm wide and 7 mm
high.
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Fig. 5B. —Aneurysm of 10-weeks' duration in New Zealand white rabbit.
Anteroposterior digital subtraction angiogram obtained 6 months after aneurysm
creation. Compared with earlier time in A, no interval change in
aneurysmal morphology is shown. Radiopaque spheres measure from 3 to 7 mm in
diameter.
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Fig. 5C. —Aneurysm of 10-weeks' duration in New Zealand white rabbit.
Photomicrograph of histopathologic specimen shows aneurysmal cavity (A), cap
of fully organized thrombus (straight arrow), and neointima
(curved arrow). No organizing thrombus is shown within aneurysmal
cavity. (H and E, x20)
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Copyright © 2000 by the American Roentgen Ray Society.
