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Diagnostic Accuracy of Thin-Section CT and Chest Radiography of Pediatric Interstitial Lung Disease

S. J. Copley1, M. Coren2, A. G. Nicholson3, M. B. Rubens1, A. Bush4 and D. M. Hansell1

1 Department of Radiology, Royal Brompton Hospital, Sydney St., London SW3 6NP, United Kingdom.
2 Department of Paediatrics, St. Mary's Hospital, Praed St., London W2 1NY, United Kingdom.
3 Department of Histopathology, Royal Brompton Hospital, London SW3 6NP, United Kingdom.
4 Department of Paediatrics, Royal Brompton Hospital, London SW3 6NP, United Kingdom.



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  		Fig. 1A. —10-month-old female infant with biopsy-proven nonspecific interstitial pneumonitis. Thin-section CT scan of upper zones shows predominant honeycomb pattern.

 


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  		Fig. 1B. —10-month-old female infant with biopsy-proven nonspecific interstitial pneumonitis. Thin-section CT scan of lower zones shows widespread ground-glass opacification.

 


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  		Fig. 2A. —13-year-old girl with biopsy-proven desquamative interstitial pneumonitis. Thin-section CT scan of upper zones shows predominant honeycomb pattern.

 


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  		Fig. 2B. —13-year-old girl with biopsy-proven desquamative interstitial pneumonitis. Thin-section CT scan of lower zones shows widespread ground-glass opacification. Appearances are similar to those seen in Figure 1A, 1B.

 


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  		Fig. 3. —2-year-old boy with biopsy-proven desquamative interstitial pneumonitis and Gaucher's disease. Thin-section CT scan shows widespread ground-glass opacification and denser parenchymal opacification in dependent lung.

 


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  		Fig. 4. —13-year-old girl with biopsy-proven lymphocytic interstitial pneumonia. Patient was immunocompromised because of postviral neutropenia. Thin-section CT scan shows profuse nodules (2-3 mm in diameter) with random distribution.

 


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  		Fig. 5. —8-year-old boy with biopsy-proven pulmonary lymphangiomatosis. Thin-section CT scan shows bilateral pleural effusions, thickened interlobular septa, and thickened bronchovascular bundles. Features are also seen in congenital lymphangiectasia, and this patient was confidently diagnosed by both observers as having latter condition.

 


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  		Fig. 6. —3-year-old girl with pulmonary alveolar proteinosis. Thin-section CT scan shows typical features of thickened interlobular septa on background of ground-glass opacification.

 

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