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Dynamic Contrast-Enhanced MR Imaging of Bacterial Abscess and VX2 Carcinoma in Rabbits

Comparison of Gadopentetate Dimeglumine and a Macromolecular Contrast Agent

¹ Department of Radiology and Clinical Research Institute, Seoul National University Hospital and the Institute of Radiation Medicine, SNUMRC 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
² Contrast Media Research, Schering, Mullerstra. 178, 13353 Berlin, Germany.

View larger version (102K): [in a new window]   Fig. 1A. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in rabbit thigh. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of Gadomer-17 (Schering, Berlin, Germany). Rim enhancement of lesion is initially weak, but gradual increase of enhancement is seen in both bacterial abscess and VX2 carcinoma.

View larger version (96K): [in a new window]   Fig. 1B. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in rabbit thigh. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of Gadomer-17 (Schering, Berlin, Germany). Rim enhancement of lesion is initially weak, but gradual increase of enhancement is seen in both bacterial abscess and VX2 carcinoma.

View larger version (99K): [in a new window]   Fig. 1C. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in rabbit thigh. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of Gadomer-17 (Schering, Berlin, Germany). Rim enhancement of lesion is initially weak, but gradual increase of enhancement is seen in both bacterial abscess and VX2 carcinoma.

View larger version (96K): [in a new window]   Fig. 1D. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in rabbit thigh. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of Gadomer-17 (Schering, Berlin, Germany). Rim enhancement of lesion is initially weak, but gradual increase of enhancement is seen in both bacterial abscess and VX2 carcinoma.

View larger version (104K): [in a new window]   Fig. 2A. —4-month old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in the same animal as in Figure 1A,1B,1C,1D. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of gadopentetate dimeglumine. Earlier and stronger rim enhancement of bacterial abscess and VX2 carcinoma is seen after injection of gadopentetate dimeglumine compared with Gadomer-17 (Schering, Berlin, Germany). Image of VX2 carcinoma obtained 30 min after the injection (D) shows washout of contrast agent in periphery and fill-in of contrast agent in center.

View larger version (85K): [in a new window]   Fig. 2B. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in the same animal as in Figure 1A,1B,1C,1D. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of gadopentetate dimeglumine. Earlier and stronger rim enhancement of bacterial abscess and VX2 carcinoma is seen after injection of gadopentetate dimeglumine compared with Gadomer-17 (Schering, Berlin, Germany). Image of VX2 carcinoma obtained 30 min after the injection (D) shows washout of contrast agent in periphery and fill-in of contrast agent in center.

View larger version (87K): [in a new window]   Fig. 2C. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in the same animal as in Figure 1A,1B,1C,1D. Images were obtained before (A) and 1 min (B), 5 min (C), and 30 min (D) after injection of gadopentetate dimeglumine. Earlier and stronger rim enhancement of bacterial abscess and VX2 carcinoma is seen after injection of gadopentetate dimeglumine compared with Gadomer-17 (Schering, Berlin, Germany). Image of VX2 carcinoma obtained 30 min after the injection (D) shows washout of contrast agent in periphery and fill-in of contrast agent in center.

View larger version (86K): [in a new window]   Fig. 2D. —4-month-old female New Zealand white rabbit. Dynamic contrast-enhanced fast spin-echo MR images (450/16 [TR/TE]) show bacterial abscess (left side, open arrow) and VX2 carcinoma (right side, solid arrow) in the same animal as in Figure 1A,1B,1C,1D. Images were obtained before (A), and 1 min (B), 5 min (C), and 30 min (D) after injection of gadopentetate dimeglumine. Earlier and stronger rim enhancement of bacterial abscess and VX2 carcinoma is seen after injection of gadopentetate dimeglumine compared with Gadomer-17 (Schering, Berlin, Germany). Image of VX2 carcinoma obtained 30 min after the injection (D) shows washout of contrast agent in periphery and fill-in of contrast agent in center.

View larger version (19K): [in a new window]   Fig. 3. —Graph shows mean enhancement ratio after injection of (0.05 mmol/kg) Gadomer-17 (Schering, Berlin Germany) in bacterial abscess and VX2 carcinoma. Delayed peak enhancement and slow decay are seen in both bacterial abscess and VX2 carcinoma after injection. Enhancement ratios of VX2 carcinoma are significantly higher than those of bacterial abscess at 2-30 min after the injection (p < 0.05). Error bars represent one standard deviation. Open triangles represent bacterial abscess. Solid rectangles represent VX2 carcinoma.

View larger version (23K): [in a new window]   Fig. 4. —Graph shows mean enhancement ratio after injection of gadopentetate dimeglumine (0.1 mmol/kg) in bacterial abscess and VX2 carcinoma. Compared with Gadomer-17 (Schering, Berlin, Germany), early peak enhancement in both bacterial abscess and VX2 carcinoma and rapid decay in VX2 carcinoma are seen after injection. Enhancement ratios of VX2 carcinoma are significantly higher at 1 min but significantly lower at 20-30 min after the injection as compared with those of bacterial abscess (p < 0.05). Error bars represent one standard deviation. Open triangles represent bacterial abscess. Solid rectangles represent VX2 carcinoma.

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