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Quantitative Comparison of Intrabrain Diffusion in Adults and Preterm and Term Neonates and Infants

Steven F. Tanner1, Luca A. Ramenghi2, John P. Ridgway1, Elizabeth Berry1, Margaret A. Saysell3, Delia Martinez3, Rosemary J. Arthur3, Michael A. Smith1 and Malcolm I. Levene2

1 Department of Medical Physics and Centre of Medical Imaging Research, University of Leeds, The Wellcome Wing, Leeds General Infirmary, Gt. George St., Leeds LS1 3EX, United Kingdom.
2 Centre for Reproduction, Growth and Development, University of Leeds, D Fl. Clarendon Wing, Leeds General Infirmary, Leeds LS2 9NS, United Kingdom.
3 Department of Paediatric Radiology, University of Leeds, Clarendon Wing, Leeds General Infirmary, Leeds LS2 9NS, United Kingdom.



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  		Fig. 1A. —Diffusion-weighted MR images of 4-week-old male neonate with postmenstrual age of 33 weeks. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 1B. —Diffusion-weighted MR images of 4-week-old male neonate with postmenstrual age of 33 weeks. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 1C. —Diffusion-weighted MR images of 4-week-old male neonate with postmenstrual age of 33 weeks. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 2A. —Diffusion-weighted MR images of 1-day-old female neonate born at term. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 2B. —Diffusion-weighted MR images of 1-day-old female neonate born at term. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 2C. —Diffusion-weighted MR images of 1-day-old female neonate born at term. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 3A. —Diffusion-weighted MR images of 4-month-old male infant. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 3B. —Diffusion-weighted MR images of 4-month-old male infant. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 3C. —Diffusion-weighted MR images of 4-month-old male infant. Images acquired with diffusion sensitization (b = 1000 sec mm-2) applied in left-right (A), anterior-posterior (B), and through-plane (C) directions.

 


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  		Fig. 4. —MR image mapping quantitative values of apparent diffusion coefficient (Dav) in brain of 12-day-old female neonate with postmenstrual age of 35 weeks. Values of nonlinear scale should be multiplied by 10-3 mm2 s-1 to obtain value of Dav.

 


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  		Fig. 5. —MR image mapping quantitative values of apparent diffusion coefficient (Dav) in brain of 1-day-old female neonate born at term. Values of nonlinear scale should be multiplied by 10-3 mm2 s-1 to obtain value of Dav.

 


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  		Fig. 6. —MR image mapping quantitative values of apparent diffusion coefficient (Dav) in brain of 8-month-old female infant. Values of nonlinear scale should be multiplied by 10-3 mm2 s-1 to obtain value of Dav.

 


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  		Fig. 7. —MR image mapping quantitative values of apparent diffusion coefficient (Dav) in brain of 20-year-old woman. Values of nonlinear scale should be multiplied by 10-3 mm2 s-1 to obtain value of Dav.

 

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