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CT Features of Castleman Disease of the Abdomen and Pelvis

Toni L. Meador1,2 and John K. McLarney1,3

1 Department of Radiologic Pathology, Armed Forces Institute of Pathology, Rm. M-111, 14th St. N.W. and Alaska Ave., Washington, DC 20306-6000.
2 Present address: Asheville Radiology Associates, P. O. Box 2959, Asheville, NC 28802.
3 Present address: Department of Radiology, USA MEDDAC, Fort Carson, CO 80913.



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  		Fig. 1A. —9-year-old boy who presented with abdominal pain. Contrast-enhanced pelvic CT scan shows well-defined, homogeneously enhancing mass (arrow). Surgical pathology revealed hyaline-vascular type Castleman disease.

 


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  		Fig. 1B. —9-year-old boy who presented with abdominal pain. Photomicrograph of histopathologic specimen shows typical target appearance of follicular center in hyaline-vascular type Castleman disease. (H and E)

 


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  		Fig. 1C. —9-year-old boy who presented with abdominal pain. Photomicrograph of histopathologic specimen shows concentric-ring pattern of flattened cells, hyalinized germinal center, and capillary proliferation. (H and E)

 


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  		Fig. 2. —46-year-old man. Clinical presentation history was not available. Contrast-enhanced abdominal CT scan shows well-defined heterogeneously enhancing retroperitoneal mass. Surgical pathology revealed hyaline-vascular type Castleman disease.

 


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  		Fig. 3. —43-year-old woman who presented with abdominal pain. Contrast-enhanced CT scan shows heterogeneously enhancing mass with "arborizing" or radial pattern of calcification. Less than 1-cm aortocaval lymph nodes are identified. Surgical pathology revealed mixed-type Castleman disease.

 

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