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Characterization of Focal Hepatic Lesions with Ferumoxides-Enhanced T2-Weighted MR Imaging

Mark R. Paley1,2, Patricia J. Mergo1, Gladys M. Torres1 and Pablo R. Ros3

1 Division of Body Imaging and MRI, Department of Radiology, University of Florida College of Medicine, Box 100374, 1600 S.W. Archer Rd., Gainesville, FL 32610.
2 Present address: Department of Radiology, Frimley Park Hospital, Portsmouth Rd., Frimley, Camberley, Surrey, GU16 5UJ, United Kingdom.
3 Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis St., Boston, MA 02115.



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  		Fig. 1. —Graph shows signal-to-noise ratio of lesions on T2-weighted images before and after ferumoxides enhancement. Note that benign lesions show reduction in signal-to-noise ratio as opposed to malignant lesions. White and gray bars indicate unenhanced and ferumoxides-enhanced, respectively. Mets = metastases, HCC = hepatocellular carcinoma, Chol = cholangiocarcinoma, Hem = hemangioma, FNH = focal nodular hyperplasia, HCA = hepatocellular adenoma.

 


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  		Fig. 2. —Graph shows lesion signal intensity change on T2-weighted images after ferumoxides enhancement. Note that focal nodular hyperplasia shows significant reduction in signal intensity. Mets = metastases, HCC = hepatocellular carcinoma, Chol = cholangiocarcinoma, Hem = hemangioma, FNH = focal nodular hyperplasia, HCA = hepatocellular adenoma.

 


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  		Fig. 3A. —Focal nodular hyperplasia in 43-year-old woman. Unenhanced T2-weighted spin-echo MR image shows lesion (arrow) as well circumscribed and, in right lobe, mildly hyperintense to liver.

 


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  		Fig. 3B. —Focal nodular hyperplasia in 43-year-old woman. Ferumoxides-enhanced T2-weighted spin-echo MR image shows decrease in signal intensity of lesion, liver, and spleen, and increased conspicuity of hyperintense central scar.

 


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  		Fig. 4A. —Sarcoma metastases in 66-year-old woman. Unenhanced T2-weighted spin-echo MR image shows large lobulated hyperintense lesion in left lobe and smaller lesions in right lobe.

 


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  		Fig. 4B. —Sarcoma metastases in 66-year-old woman. Ferumoxides-enhanced T2-weighted spin-echo MR image shows decrease in signal intensity of background liver, increasing liver-to-lesion contrast for both large and small lesions.

 

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