Gadolinium Mesoporphyrin as an MR Imaging Contrast Agent in the Evaluation of Tumors
An Experimental Model of VX2 Carcinoma in Rabbits
Tae Kyoung Kim1,2,
Byung Ihn Choi1,2,
Sun Won Park1,
Whal Lee1,
Joon Koo Han1,2,
Man Chung Han1,2 and
Hans-Joachim Weinmann3
1
Department of Radiology, Seoul National University College of Medicine, 28
Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
2
Clinical Research Institute, Seoul National University Hospital, 28
Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
3
Research Laboratories of Schering AG, D 13342, Berlin, Germany.
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Fig. 1A. —Rabbit thigh with VX2 carcinoma (3-4 days after tumor inoculation).
Axial T1-weighted spin-echo MR image (TR/TE, 500/20) shows slightly
hyperintense mass (arrow) with irregular margin.
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Fig. 1B. —Rabbit thigh with VX2 carcinoma (3-4 days after tumor inoculation).
T1-weighted spin-echo MR image (500/20) obtained 2 min after IV injection of
gadopentetate dimeglumine shows diffuse enhancement of entire lesion
(solid arrow). Note hypointense area (open arrow) surrounded
by enhanced area.
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Fig. 1C. —Rabbit thigh with VX2 carcinoma (3-4 days after tumor inoculation).
T1-weighted spin-echo MR image (500/20) obtained 20 hr after IV injection of
gadolinium mesoporphyrin shows diffuse enhancement of entire lesion
(arrow) similar to that in B.
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Fig. 1D. —Rabbit thigh with VX2 carcinoma (3-4 days after tumor inoculation).
Photomicrograph shows viable tumor cells (solid arrows) with
granulation tissue and fibrosis (arrowheads) infiltrating muscle
bundles in thigh. Thick longitudinally oriented muscle bundle (open
arrow) is visible in area that corresponds with hypointense area in
B. On MR images, enhanced areas correspond to viable tumor tissue and
nontumorous areas, including granulation tissue and fibrosis. (H and E,
x5)
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Fig. 2A. —Rabbit thigh with VX2 carcinoma (6-7 days after tumor inoculation).
Axial T2-weighted spin-echo MR image (TR/TE, 2000/70) shows heterogeneously
hyperintense mass in right thigh.
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Fig. 2B. —Rabbit thigh with VX2 carcinoma (6-7 days after tumor inoculation).
T1-weighted spin-echo MR image (500/20) obtained 2 min after IV injection of
gadopentetate dimeglumine shows thick rim of enhancement at periphery of mass
and nodular thickening of enhanced rim (arrow) in right posterior
aspect of lesion.
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Fig. 2C. —Rabbit thigh with VX2 carcinoma (6-7 days after tumor inoculation).
T1-weighted spin-echo MR image (500/20) obtained 20 hr after IV injection of
gadolinium mesoporphyrin shows thick rim of enhancement at periphery of mass
and nodular thickening of enhanced rim in right posterior aspect of lesion.
Additionally, mild homogeneous enhancement is visible in central portion of
lesion (arrow).
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Fig. 2D. —Rabbit thigh with VX2 carcinoma (6-7 days after tumor inoculation).
Photomicrograph shows necrotic debris (solid arrow) surrounded by
thick fibrous capsule (arrowheads). Viable tumor tissue is present
only in right posterior aspect of lesion (open arrow), corresponding
with nodular thickening of enhanced rim on MR images (arrow,
B). Peripheral enhanced rim on MR images represents thick fibrous
capsule without viable tumor cells. Central mildly enhanced area with
gadolinium mesoporphyrin (arrow, C) represents necrotic area
with tissue debris. (H and E, x5)
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Fig. 3A. —Rabbit thigh with VX2 carcinoma (13-14 days after tumor inoculation
in right thigh and 10-11 days after tumor inoculation in left thigh).
T1-weighted spin-echo MR image (TR/TE, 500/20) obtained 2 min after IV
injection of gadopentetate dimeglumine shows diffuse enhancement of masses in
bilateral thighs. Multiple irregular intratumoral unenhanced areas
(arrows) are visible in right thigh.
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Fig. 3B. —Rabbit thigh with VX2 carcinoma (13-14 days after tumor inoculation
in right thigh and 10-11 days after tumor inoculation in left thigh).
T1-weighted spin-echo MR image (500/20) obtained 20 hr after IV injection of
gadolinium mesoporphyrin shows diffuse enhancement of masses in thighs.
Irregular areas with relatively mild enhancement (arrows) are visible
in mass in right thigh.
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Fig. 3C. —Rabbit thigh with VX2 carcinoma (13-14 days after tumor inoculation
in right thigh and 10-11 days after tumor inoculation in left thigh).
Photomicrograph shows two lobulated tumors surrounded by thin fibrous capsule
(arrowheads) in bilateral thighs. Intratumoral unenhanced areas with
gadopentetate dimeglumine in right thigh (arrows, A) represent
necrosis and hemorrhage in tumor (arrows). Areas with relatively mild
enhancement with gadolinium mesoporphyrin (arrows, B)
correspond to part of tumor necrosis. (H and E, x3)
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