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Assessment of Coronary Flow Reserve Using Fast Velocity-Encoded Cine MR Imaging

Validation Study Using Positron Emission Tomography

Hajime Sakuma1, Juha W. Koskenvuo2, Pekka Niemi3, Nanaka Kawada1, Jyri O. Toikka2, Juhani Knuuti4, Hanna Laine4, Markku Saraste2, Martti Kormano3 and Jaakko J. Hartiala2

1 Department of Radiology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie 514-8507, Japan.
2 Department of Clinical Physiology, Turku University Central Hospital, 20520 Turku, Finland.
3 Department of Radiology, Turku University Central Hospital, 20520 Turku, Finland.
4 Turku PET Centre, Turku University, 20520 Turku, Finland.



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  		Fig. 1A. —27-year-old healthy male volunteer. Magnitude (A) and phase-difference (B) MR images acquired with fast velocity-encoded cine MR imaging show left anterior descending artery (arrows).

 


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  		Fig. 1B. —27-year-old healthy male volunteer. Magnitude (A) and phase-difference (B) MR images acquired with fast velocity-encoded cine MR imaging show left anterior descending artery (arrows).

 


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  		Fig. 2. —MR imaging blood flow velocity curves in left anterior descending artery in 27-year-old healthy male volunteer both in baseline state and after dipyridamole administration. Note that flow velocity in left anterior descending artery increased after dipyridamole injection.

 


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  		Fig. 3. —Scatter diagram for 27-year-old healthy male volunteer shows correlation between velocity flow reserve in left anterior descending artery measured on fast velocity-encoded cine MR images and myocardial perfusion reserve in anterior myocardium measured on positron emission tomography (PET). Note that MR imaging and PET assessments of coronary flow reserve showed a significant linear correlation (r=0.79, y=0.58, x+1.1).

 

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