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Reproducibility of Hippocampal Single-Voxel Proton MR Spectroscopy and Chemical Shift Imaging

¹ Department of Radiology, Chang Gung Memorial Hospital, 199 Tun-Hwa North Rd., Taipei, Taiwan 105, R.O.C.
² Department of Public Health, Chang Gung University, 259 Wen-Hwa First Rd., Kweishan, Taoyuan, Taiwan 333, R.O.C.
³ Institute of Biomedical Science, Academia Sinica, 128 Yen-Jo-Yuan Rd., Nangung, Taipei, Taiwan 115, R.O.C.

View larger version (123K): [in a new window]   Fig. 1A. —20-year-old healthy man. Transverse T2-weighted MR image shows volume of interest of single-voxel spectroscopy within left hippocampus.

View larger version (127K): [in a new window]   Fig. 1B. —20-year-old healthy man. T2-weighted MR image shows volume of interest of unilateral chemical shift imaging within left hippocampus.

View larger version (120K): [in a new window]   Fig. 1C. —20-year-old healthy man. T2-weighted MR image shows volume of interest of chemical shift imaging that encompassed bilateral hippocampi.

View larger version (63K): [in a new window]   Fig. 1D. —20-year-old healthy man. Spectrum of single-voxel spectroscopy shows integral values of three major peaks: N-acetylaspartate at 2.00 parts per million (ppm), creatine—phosphocreatine at 3.02 ppm, and choline-containing compounds at 3.22 ppm.

View larger version (104K): [in a new window]   Fig. 1E. —20-year-old healthy man. Spectral map of unilateral chemical shift imaging of left hippocampus.

View larger version (118K): [in a new window]   Fig. 1F. —20-year-old healthy man. Right anterior portion of spectral map of bilateral chemical shift imaging study shows eight voxels in 2 x 4 matrix, anatomically corresponding to those in unilateral chemical shift imaging.

View larger version (14K): [in a new window]   Fig. 2A. —Graphs show left hippocampal NAA/(Cho+Cr) ratios. Every subject had four measurements on 3 days. Measurements 1-1 () and 1-2 ([UNK]) are performed continuously without changing volume of interest to evaluate within-acquisition reproducibility. Measurements 2 () and 3 () and the first one of the continuous measurements (i.e., measurement 1-1) are for evaluation of between-acquisition reproducibility. Single-voxel spectroscopic studies. Line and dash lines show mean and standard deviation, respectively.

View larger version (15K): [in a new window]   Fig. 2B. —Graphs show left hippocampal NAA/(Cho+Cr) ratios. Every subject had four measurements on 3 days. Measurements 1-1 () and 1-2 ([UNK]) are performed continuously without changing volume of interest to evaluate within-acquisition reproducibility. Measurements 2 () and 3 () and the first one of the continuous measurements (i.e., measurement 1-1) are for evaluation of between-acquisition reproducibility. Unilateral chemical shift imaging studies. Range of mean ± standard deviation in posterior hippocampus (C) is much smaller than that in anterior hippocampus (B).

View larger version (15K): [in a new window]   Fig. 2C. —Graphs show left hippocampal NAA/(Cho+Cr) ratios. Every subject had four measurements on 3 days. Measurements 1-1 () and 1-2 ([UNK]) are performed continuously without changing volume of interest to evaluate within-acquisition reproducibility. Measurements 2 () and 3 () and the first one of the continuous measurements (i.e., measurement 1-1) are for evaluation of between-acquisition reproducibility. Unilateral chemical shift imaging studies. Range of mean ± standard deviation in posterior hippocampus (C) is much smaller than that in anterior hippocampus (B).

View larger version (15K): [in a new window]   Fig. 2D. —Graphs show left hippocampal NAA/(Cho+Cr) ratios. Every subject had four measurements on 3 days. Measurements 1-1 () and 1-2 ([UNK]) are performed continuously without changing volume of interest to evaluate within-acquisition reproducibility. Measurements 2 () and 3 () and the first one of the continuous measurements (i.e., measurement 1-1) are for evaluation of between-acquisition reproducibility. Chemical shift imaging studies that encompassed bilateral hippocampi. Range of means ± standard deviation of posterior hippocampus (E) is much smaller than that of anterior hippocampus (D).

View larger version (15K): [in a new window]   Fig. 2E. —Graphs show left hippocampal NAA/(Cho+Cr) ratios. Every subject had four measurements on 3 days. Measurements 1-1 () and 1-2 ([UNK]) are performed continuously without changing volume of interest to evaluate within-acquisition reproducibility. Measurements 2 () and 3 () and the first one of the continuous measurements (i.e., measurement 1-1) are for evaluation of between-acquisition reproducibility. Chemical shift imaging studies that encompassed bilateral hippocampi. Range of means ± standard deviation of posterior hippocampus (E) is much smaller than that of anterior hippocampus (D).

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