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Paclitaxel-Induced Hypersensitivity Pneumonitis

Radiographic and CT Findings

Patricia Wong1, Ann N. Leung1, Gerald J. Berry2, Kristin A. Atkins2, Jose G. Montoya3, Stephen J. Ruoss4 and Frank E. Stockdale5

1 Department of Radiology, S072A, Stanford University Medical Center, Stanford, CA 94305-5105.
2 Department of Pathology, Stanford University Medical Center, Stanford, CA 94305-5105.
3 Division of Infectious Diseases, Stanford University Medical Center, Stanford, CA 94305-5105.
4 Division of Pulmonary and Critical Care, Stanford University Medical Center, Stanford, CA 94305-5105.
5 Division of Oncology, Stanford University Medical Center, Stanford, CA 94305-5105.



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  		Fig. 1A. —61-year-old woman with paclitaxel-induced hypersensitivity pneumonitis. Close-up radiographic view of left upper lung zone shows reticulonodular opacities.

 


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  		Fig. 1B. —61-year-old woman with paclitaxel-induced hypersensitivity pneumonitis. CT scan (7-mm collimation) shows bilateral patchy areas of increased parenchymal attenuation in upper lobes.

 


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  		Fig. 1C. —61-year-old woman with paclitaxel-induced hypersensitivity pneumonitis. Intermediate power microscopy shows temporally uniform cellular mononuclear-cell interstitial pneumonitis without vasculitic or neoplastic changes. (H and E, x200) Insert shows high-power view of histiocytic collections forming vague granulomas. (H and E, x500)

 

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