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Accuracy for Detection of Simulated Lesions

Comparison of Fluid-Attenuated Inversion-Recovery, Proton Density-Weighted, and T2-Weighted Synthetic Brain MR Imaging

Edward H. Herskovits1,2, Ryuta Itoh1,3 and Elias R. Melhem1,3,4

1 Division of Neuroradiology, The Johns Hopkins Medical Institutions, 600 N. Wolfe St., Baltimore, MD 21287-7619.
2 Department of Biostatistics, The Johns Hopkins School of Public Health, Baltimore, MD 21287.
3 The MR Perception Laboratory of The Kennedy Krieger Institute, Baltimore, MD 21287.
4 Department of Radiology, The Johns Hopkins Hospital, 600 N. Wolfe St., Baltimore, MD 21287-2182.



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  		Fig. 1. —Simulation of heterogeneous lesion. Value for each of 37 pixels is calculated using relaxation times (T1/T2) for lesion core (pixels with asterisk), middle layer (gray pixels), and peripheral layer (white pixels) of 1515/104, 1450/99, and 1384/95, respectively.

 


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  		Fig. 2A. —Computer-generated T2-weighted MR images of brain at level of lateral ventricles. Images obtained contain simulated lesions with fixed pixel values throughout each lesion (A) and variable pixel values throughout each lesion (B). Individual simulated lesions (arrow) in B were judged to be more realistic and thus to better approximate brain lesions encountered in clinical practice than corresponding simulated lesions (arrow) in A.

 


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  		Fig. 2B. —Computer-generated T2-weighted MR images of brain at level of lateral ventricles. Images obtained contain simulated lesions with fixed pixel values throughout each lesion (A) and variable pixel values throughout each lesion (B). Individual simulated lesions (arrow) in B were judged to be more realistic and thus to better approximate brain lesions encountered in clinical practice than corresponding simulated lesions (arrow) in A.

 


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  		Fig. 3A. —Computer-generated brain images at level of lateral ventricles with representative simulated lesions in cortical-subcortical (arrowhead), deep white matter (large arrow), and periventricular (small arrow) regions. Fluid-attenuated inversion-recovery image.

 


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  		Fig. 3B. —Computer-generated brain images at level of lateral ventricles with representative simulated lesions in cortical-subcortical (arrowhead), deep white matter (large arrow), and periventricular (small arrow) regions. Proton density-weighted image.

 


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  		Fig. 3C. —Computer-generated brain images at level of lateral ventricles with representative simulated lesions in cortical-subcortical (arrowhead), deep white matter (large arrow), and periventricular (small arrow) regions. T2-weighted image.

 

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