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Ten Criteria for Effective Screening

Their Application to Multislice CT Screening for Pulmonary and Colorectal Cancers

Nancy A. Obuchowski1,2, Ruffin J. Graham2, Mark E. Baker2 and Kimerly A. Powell3

1 Department of Biostatistics and Epidemiology/Wb4, The Cleveland Clinic Foundation, 9500 Euclid Ave., Cleveland, OH 44195.
2 Division of Radiology, The Cleveland Clinic Foundation, Cleveland, OH 44195.
3 Department of Biomedical Engineering, Lerner Research Institute, The Cleveland Clinic Foundation, Cleveland, OH 44195.



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  		Fig. 1. —Diagram shows individual's time line from birth to death. Preclinical phase of disease begins with onset and ends when signs and symptoms appear. Clinical phase begins with onset of signs and symptoms. Detectable preclinical phase (DPCP) is interval of time during preclinical phase when disease is detectable by test. Lead time is interval of time from disease detection to appearance of signs and symptoms. For screening to be effective, critical point (CP) must occur during DPCP. (Adapted from [5])

 

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