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Detection of Renal Artery Stenosis

Prospective Comparison of Captopril-Enhanced Doppler Sonography, Captopril-Enhanced Scintigraphy, and MR Angiography

Salah D. Qanadli1, Gilles Soulez1, Eric Therasse2, Viviane Nicolet1, Sophie Turpin3, Daniel Froment4, Maryse Courteau4, Marie-Claude Guertin5 and Vincent L. Oliva1

1 Department of Radiology, CHUM, Hôpital Notre-Dame, 1560 Sherbrooke St. E., Montréal, Quebec H2L 4M1, Canada.
2 Department of Radiology, CHUM, Hôpital Hotel-Dieu de Montréal, University of Montréal, 3840 St. Urbain, H2W 1T8 Montréal, Quebec, Canada.
3 Department of Nuclear Medicine, CHUM, Hôpital Hotel-Dieu de Montréal, University of Montréal, H2W 1T8 Montréal, Quebec, Canada.
4 Department of Medicine, CHUM, Hôpital Notre-Dame, Montréal, Quebec H2L 4M1, Canada.
5 Department of Biostatistics, Hotel-Dieu de Montréal, University of Montréal, Montréal, Quebec H2L 4M1, Canada.



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Fig. 1A. 76-year-old man with severe hypertension. Radiologic investigation revealed discrepancy between MR angiography and catheter angiography. Catheter angiogram reveals bilateral renal artery stenosis. Right renal artery stenosis (arrow) was considered meaningful using 50% threshold and insignificant using 70% threshold (measurement of investigator 1: 54%; investigator 2: 64%). Similarly, left renal artery stenosis (arrowhead) was meaningful for 50% threshold and insignificant for 70% threshold (investigator 1: 58%; investigator 2: 54%).

 


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Fig. 1B. 76-year-old man with severe hypertension. Radiologic investigation revealed discrepancy between MR angiography and catheter angiography. Maximum-intensity-projection reconstruction obtained from gadolinium-enhanced MR angiography shows bilateral renal artery stenoses. However, degree of stenosis was overestimated as compared with catheter angiography. Right renal artery stenosis (long arrow) was considered meaningful using 70% threshold by second investigator (investigator 1, 63%; investigator 2: 71%) and left renal artery stenosis (short arrow) was considered meaningful using 70% threshold by first investigator (investigator 1: 75%; investigator 2: 61%), thus resulting in false-positive results for gadolinium-enhanced MR angiography.

 


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Fig. 1C. 76-year-old man with severe hypertension. Radiologic investigation revealed discrepancy between MR angiography and catheter angiography. Intrarenal Doppler waveform obtained from right kidney 1 hr after captopril administration. Systolic rise is perfectly straight (arrow), indicating a normal finding. Left renal Doppler study had equally normal findings.

 

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