Functional MR Imaging of Regional Brain Activation Associated with the Affective Experience of Pain
Robert K. Fulbright1,
Clemens J. Troche1,
Pawel Skudlarski1,
John C. Gore1,2 and
Bruce E. Wexler3
1
Section of Neuroradiology, Department of Diagnostic Radiology, Yale University
School of Medicine, Box 208042, 333 Cedar St., New Haven, CT 06520-8042.
2
Department of Applied Physics, Yale University School of Medicine, Yale
University, New Haven, CT 06520.
3
Department of Psychiatry, Yale University School of Medicine, New Haven, CT
06520.
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Fig. 1A. —Functional MR images (group composite) of regional brain
activation during cold task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in cold task compared with
baseline task. Blue—purple areas indicate brain regions that were more
active (p < 0.01) in baseline task than in cold task. Arrow
indicates only site in which anterior cingulate gyrus was active during cold
task; z-axis slice location is 40.
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Fig. 1B. —Functional MR images (group composite) of regional brain
activation during cold task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in cold task compared with
baseline task. Blue—purple areas indicate brain regions that were more
active (p < 0.01) in baseline task than in cold task. Cold-related
activation is seen in postcentral gyrus, bilaterally (arrows) and in
right middle frontal gyrus (arrowhead); z-axis slice
location is 32.
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Fig. 1C. —Functional MR images (group composite) of regional brain
activation during cold task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in cold task compared with
baseline task. Blue—purple areas indicate brain regions that were more
active (p < 0.01) in baseline task than in cold task. Activation
in cold task occurs in left middle frontal gyrus and adjacent superior frontal
sulcus (arrowhead), right inferior frontal gyrus (curved
arrow), and left postcentral gyrus activation (arrow);
z-axis slice location is 24.
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Fig. 1D. —Functional MR images (group composite) of regional brain
activation during cold task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in cold task compared with
baseline task. Blue—purple areas indicate brain regions that were more
active (p < 0.01) in baseline task than in cold task. Left
anterior insula (arrowhead) and right subcentral gyrus
(arrow) are active during cold task; z-axis slice location
is 12.
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Fig. 1E. —Functional MR images (group composite) of regional brain
activation during cold task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in cold task compared with
baseline task. Blue—purple areas indicate brain regions that were more
active (p < 0.01) in baseline task than in cold task. Activation
with cold stimulus is seen in left thalamus (arrowhead);
z-axis slice location is 4.
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Fig. 2A. —Functional MR images (group composite) of regional brain
activation during pain task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in pain task compared with cold
task. Blue—purple areas indicate brain regions that were more active
(p < 0.01) in cold task compared with pain task. Activation during
pain task is depicted in anterior cingulate gyrus (arrows) and
superior frontal gyri (arrowhead); z-axis slice location is
40.
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Fig. 2B. —Functional MR images (group composite) of regional brain
activation during pain task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in pain task compared with cold
task. Blue—purple areas indicate brain regions that were more active
(p < 0.01) in cold task compared with pain task. Pain-related
activation is seen in anterior cingulate gyrus (straight arrow), in
superior frontal gyrus bilaterally (arrowheads), and in right cuneus
(curved arrow); z-axis slice location is 32.
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Fig. 2C. —Functional MR images (group composite) of regional brain
activation during pain task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in pain task compared with cold
task. Blue—purple areas indicate brain regions that were more active
(p < 0.01) in cold task compared with pain task. Anterior
cingulate gyrus (arrow) is activated by pain stimulus;
z-axis slice location is 24.
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Fig. 2D. —Functional MR images (group composite) of regional brain
activation during pain task. Red—yellow areas represent brain regions
that were more active (p < 0.01) in pain task compared with cold
task. Blue—purple areas indicate brain regions that were more active
(p < 0.01) in cold task compared with pain task. Region of right
superior frontal gyrus and sulcus is active (arrowhead) during pain
task; z-axis slice location is 12.
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Copyright © 2001 by the American Roentgen Ray Society.
