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Using Highly Concentrated Gadobutrol as an MR Contrast Agent in Patients Also Requiring Hemodialysis

Safety and Dialysability

Bernd Tombach1, Christoph Bremer1, Peter Reimer2, Fritz Matzkies3, Roland M. Schaefer3, Wolfgang Ebert4, Viviane Geens4, Jeffrey Eisele4 and Walter Heindel1

1 Department of Clinical Radiology, Westfalian Wilhelms-University of Muenster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany.
2 Department of Radiology, Karlsruhe, Academic Teaching Hospital of Freiburg, Germany.
3 Department of Internal Medicine, Westfalian Wilhelms-University of Muenster, Germany.
4 Schering, Berlin, Germany.



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  		Fig. 1. —Bar graph shows total eliminated fraction (mean ± SD) of 1 mol/L gadobutrol after 3 hr of hemodialysis using a 1.2 m2 low-flux polysulfone membrane. [UNK] = 0.1 mmol of gadolinium per kilogram of body weight; {blacksquare} = 0.3 mmol of gadolinium per kilogram of body weight.

 


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  		Fig. 2. —Bar graph shows clearance (mean ± SD) of 1 mol/L gadobutrol calculated during first hemodialysis session at 30 and 90 min into the procedure. [UNK] = 0.1 mmol of gadolinium per kilogram of body weight; {blacksquare} = 0.3 mmol of gadolinium per kilogram of body weight.

 

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