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Contrast Media Clearance in a Single Kidney Measured on Multiphasic Helical CT

Results in 50 Patients Without Acute Renal Disorder

¹ All authors: Department of Diagnostic Radiology, Justus-Liebig Universität Gießen, Klinikstr. 36, 35385 Gießen, Germany.

View larger version (9K): [in a new window]   Fig. 1. —51-year-old woman with good renal function. Serum creatinine was 0.8 mg/dL. Graph shows plasma iodine concentration measurements (circles) after CT with accurate fit (line) with C(t) = 1.62 x exp (0.025 x -t) + 1.174 x exp (0.00483 x -t). Injected dose was 120 mL iopromide. Plasma clearance was 114 mL/min. C(t) = iodine concentration at time t in milligrams per milliliter.

View larger version (10K): [in a new window]   Fig. 2. —69-year-old man with impaired renal function. Serum creatinine was 2.2 mg/dL. Graph shows plasma iodine concentration measurements (circles) with accurate fit (line) with C(t) = 1.077 x exp (0.046 x -t) + 1.39 x exp (0.00206 x -t). Injected dose was 90 mL iopromide. Plasma clearance was 39 mL/min. C(t) = iodine concentration at time t in milligrams per milliliter.

View larger version (114K): [in a new window]   Fig. 3. —59-year-old man with colon carcinoma who underwent CT performed during arterial phase. Regions of interest (ROI) of left kidney (white circle) and aorta (black circle) have been drawn manually. From kidney ROI, mean density and area were recorded. From aortic ROI, only mean density was recorded.

View larger version (16K): [in a new window]   Fig. 4. —51-year-old woman who underwent abdominal CT (same patient as shown in Fig. 1). Graph shows aortic density curve. First cluster of circles represents bolus-triggering data; subsequent three clusters were measured from arterial (5 mm), early parenchymal (8 mm), and late parenchymal (5 mm) scans. Horizontal line indicates aortic density taken as b(t) for calculation of CT clearance, which was calculated as mean value of all data points acquired during scanning of kidneys. Area under curve needed to be measured for integrals t = 0 to t1, t = 0 to t2, and t = 0 to t = t3; t1, t2, and t3 were defined as midpoint of each kidney scan (vertical lines).

View larger version (15K): [in a new window]   Fig. 5. —67-year-old woman who underwent thoracic and abdominal CT. Graph shows aortic density curve. First cluster of circles represents early thoracic scan. No bolus triggering was carried out. Some data points around 70-80 sec postinjection arise from scanning liver in portal venous phase, which was required for clinical CT indication.

View larger version (15K): [in a new window]   Fig. 6. —Graph shows correlation (r = 0.80) in 50 patients of early CT clearance with plasma clearance (y = 5.3 + 1.05 x; SDyx = 20.7 mL/min).

View larger version (14K): [in a new window]   Fig. 7. —Graph shows correlation (r = 0.64) in 50 patients of late CT clearance with plasma clearance (y = 10.5 + 0.80x; SDyx = 24.7 mL/min).

View larger version (14K): [in a new window]   Fig. 8. —Graph shows correlation (r = 0.84) in 50 patients of overall CT clearance with plasma clearance (y = 7.5 + 0.94x; SDyx = 16 mL/min).

View larger version (15K): [in a new window]   Fig. 9. —Graph shows difference between plasma clearance and overall CT clearance versus their means. Dashed line represents mean difference (d = -3 mL/min) and solid line limits of agreement; d = mean difference, s = standard deviation of differences.

View larger version (30K): [in a new window]   Fig. 10. —Graph shows intraindividual relation of early and late CT clearances. CT clearances of one patient are connected by line. Each line represents one patient.

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