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Effects of Prostaglandin E1 Injection Through the Superior Mesenteric Artery on the Hemodynamics of Hepatocellular Carcinoma

Takuji Yamagami1, Toshiyuki Nakamura, Shigeharu Iida, Takeharu Kato, Osamu Tanaka and Tsunehiko Nishimura

1 All authors: Department of Radiology, Kyoto Prefectural University of Medicine, 465 Kajii-chyo, Kawaramachi-Hirokoji, Kamigyo, Kyoto, 602-8566, Japan.



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  		Fig. 1A. —71-year-old woman with hepatocellular carcinoma. CT during arterial portography image shows round tumor (arrow) with decreased portal perfusion in segment VIII of liver.

 


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  		Fig. 1B. —71-year-old woman with hepatocellular carcinoma. CT hepatic arteriogram shows area that is isodense (arrow) compared with normal liver parenchyma, corresponding to area of decreased portal perfusion seen on CT during portography.

 


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  		Fig. 1C. —71-year-old woman with hepatocellular carcinoma. CT hepatic arteriogram obtained after intraarterial prostaglandin E1 injection shows round enhancement of tumor (arrow) that is 20 mm in diameter. CT attenuation of enhancement of this lesion is 353.0 H, whereas CT attenuation of corresponding area on CT hepatic arteriogram before prostaglandin E1 injection was 91.0 H.

 


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  		Fig. 2A. —70-year-old man with hepatocellular carcinoma. CT hepatic arteriogram shows enhanced area of tumor (arrow) that is 8 mm in diameter. CT attenuation of tumor enhancement is 197.0 H.

 


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  		Fig. 2B. —70-year-old man with hepatocellular carcinoma. CT hepatic arteriogram obtained after intraarterial prostaglandin E1 injection shows 15-mm-diameter tumor (arrow). Tumor is visualized to greater extent and with more dense enhancement than without prostaglandin E1. CT attenuation of tumor enhancement on CT hepatic arteriography after prostaglandin E1 injection is 251 H.

 


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  		Fig. 3. —Diagram shows CT attention of hepatocellular carcinoma on lesions seen on CT hepatic arteriography before and after intraarterial prostaglandin E1 (PGE1) injection. Line in each box represents median value of CT attenuation of lesions before (170.0 H) and after (204.0 H) prostaglandin E1 injection. Boxes represent 25th-75th percentile. Lines outside boxes represent 10th and 90th percentiles. Plots show lesions with CT attenuations that fall outside 10th and 90th percentile. Mean CT attenuation of lesions before and after intraarterial prostaglandin E1 injection is 176.4 ± 59.0 H and 206.6 ± 2.5 H, respectively.

 


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  		Fig. 4A. —69-year-old woman with hepatocellular carcinoma. CT during arterial portography image shows round tumor (arrow) with decreased portal perfusion in segment V of liver.

 


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  		Fig. 4B. —69-year-old woman with hepatocellular carcinoma. CT hepatic arteriogram shows enhanced area (arrow) of tumor with unclear margin. CT attenuation of tumor enhancement is 211.0 H and that of surrounding liver parenchyma is 162.0 H.

 


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  		Fig. 4C. —69-year-old woman with hepatocellular carcinoma. CT hepatic arteriogram obtained after intraarterial prostaglandin E1 injection shows round, 22-mm diameter tumor (long arrow) with distinct border. CT attenuation of tumor enhancement on CT hepatic arteriography after prostaglandin E1 injection is 222.0 H and that of surrounding liver parenchyma (thick arrow) is 140.0 H.

 

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