Pediatric Reference Data for Dual X-Ray Absorptiometric Measures of Normal Bone Density in the Distal Femur
Richard C. Henderson1,2,
Robert K. Lark1,
Jamie E. Newman3,
Heidi Kecskemthy4,
Ellen B. Fung5,6,
Jordan B. Renner7,8 and
H. Theodore Harcke9,10
1
Department of Orthopaedics, Campus Box 7055, University of North Carolina,
Chapel Hill, NC 27599.
2
Department of Pediatrics, Campus Box 7525, University of North Carolina,
Chapel Hill, NC 27599.
3
School of Public Health, Campus Box 7400, University of North Carolina, Chapel
Hill, NC 27599.
4
Department of Research, A.I. duPont Hospital for Children, 1600 Rockland Rd.,
Box 269, Wilmington, DE 19899.
5
School of Nursing, University of Pennsylvania, 420 Guardian Dr., Philadelphia,
PA 19104.
6
Present address: Department of Gastroenterology and Nutrition, Children's
Hospital, 747 Fifty-Second St., Oakland, CA 94609.
7
Department of Radiology, Campus Box 7510, University of North Carolina, Chapel
Hill, NC 27599.
8
Department of Allied Health Sciences, Campus Box 7120, University of North
Carolina, Chapel Hill, NC 27599.
9
Departments of Radiology and Pediatrics, Jefferson Medical College, 1020
Walnut St., Philadelphia, PA 19107.
10
Department of Medical Imaging, A. I. duPont Hospital for Children, Wilmington,
DE 19899.
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Fig. 1. —Photograph shows healthy 6-year-old boy positioned on table
for dual x-ray absorptiometric scan of left distal femur.
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Fig. 2. —Drawing shows three separate regions in distal femur that
were independently analyzed. Region 1 (predominately cancellous bone) was
defined as rectangle beginning at anterosuperior edge of and extending
posteriorly one half of distal femoral width across growth plate. Region 2
included full width of femur, extending proximally from top of region 1 and
encompassing transition from metaphyseal to diaphyseal bone. Region 3
(predominately cortical bone) was defined as extending proximally from top of
region 2. Height of rectangle in all regions was twice that of diaphyseal
diameter. y = diameter of femur proximally; x = width of femur distally at
growth plate.
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Fig. 5. —Bone mineral density in Caucasian girls (n = 124) in
region 3 of distal femur is shown on graph as function of age. Mean (solid
line) ± 2 standard deviations (dashed lines) as defined
by best-fit weighted cubic regression analyses are also shown. Plots for
regions 1 and 2 and for boys and girls were similar.
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Copyright © 2002 by the American Roentgen Ray Society.
, dashed line) and Caucasian girls (
, solid
line). Mean ± standard error bars are given. At all ages,
densities for boys and girls did not differ significantly (p >
0.01). Plots for regions 1 and 3 were similar.