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Using a Peptide Inhibitor of the Glycoprotein IIb/IIIa Platelet Receptor

Initial Experience in Patients with Acute Peripheral Arterial Occlusions

Hyo-Chun Yoon1,2 and Franklin J. Miller, Jr.1

1 Department of Radiology, University of Utah School of Medicine, 1A-71 SOM, 50 N. Medical Dr., Salt Lake City, UT 84132.
2 Present address: Department of Diagnostic Imaging, Kaiser Moanalua Medical Center, 3288 Moanalua Rd., Honolulu, HI 96819.



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  		Fig. 1A. —49-year-old man with acute onset left lower extremity ischemia. Preliminary angiogram shows left common iliac artery occlusion with cross-pelvic reconstitution of left internal iliac artery.

 


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  		Fig. 1B. —49-year-old man with acute onset left lower extremity ischemia. Angiogram obtained after lytic therapy reveals two foci of irregular narrowing of left common iliac artery. Hemodynamically relevant gradient was measured across superior lesion.

 


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  		Fig. 1C. —49-year-old man with acute onset left lower extremity ischemia. Angiogram obtained after stent placement shows no residual gradient.

 


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  		Fig. 2A. —68-year-old man with right femoroperoneal bypass graft occlusion. Preliminary angiogram shows infusion catheter positioned at origin of femoroperoneal bypass graft that initially could not be crossed with a guidewire.

 


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  		Fig. 2B. —68-year-old man with right femoroperoneal bypass graft occlusion. Angiogram obtained after 24 hr of lytic therapy confirms femoroperoneal bypass graft is widely patent.

 


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  		Fig. 2C. —68-year-old man with right femoroperoneal bypass graft occlusion. Angiogram just distal to peroneal anastomosis reveals focal high-grade stenosis (arrow) with collateral flow present. Short jump graft was surgically placed to bypass this lesion.

 

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