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Directed Biopsy During Contrast-Enhanced Sonography of the Prostate

Ethan J. Halpern1, Ferdinand Frauscher1, Martin Rosenberg2 and Leonard G. Gomella3

1 Department of Radiology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, 132 S. 10th St., Philadelphia, PA 19107-5244.
2 Bristol-Myers Squibb Medical Imaging, 331 Treble Cove Rd., N., Billerica, MA 01862.
3 Department of Urology, Jefferson Prostate Diagnostic Center, Thomas Jefferson University, Philadelphia, PA 19107-5244.



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  		Fig. 1A. —53-year-old man with elevated prostate-specific antigen of 9.9 ng/mL and previous sextant biopsy with negative findings. Directed biopsy of right base and mid gland showed adenocarcinoma (Gleason score, 4 + 3). Baseline transverse sonogram of prostate does not reveal lesion.

 


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  		Fig. 1B. —53-year-old man with elevated prostate-specific antigen of 9.9 ng/mL and previous sextant biopsy with negative findings. Directed biopsy of right base and mid gland showed adenocarcinoma (Gleason score, 4 + 3). Transverse sonogram obtained during contrast infusion shows increased enhancement in right base (arrows).

 


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  		Fig. 1C. —53-year-old man with elevated prostate-specific antigen of 9.9 ng/mL and previous sextant biopsy with negative findings. Directed biopsy of right base and mid gland showed adenocarcinoma (Gleason score, 4 + 3). Transverse sonogram obtained during bolus administration shows focally increased parenchymal enhancement of right base (calipers). Targeted biopsy of this site yielded positive biopsy core.

 

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