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MR Imaging Features of Infiltrating Lobular Carcinoma of the Breast

Histopathologic Correlation

¹ Department of Radiology, Box 0628, University of California San Francisco, 505 Parnassus Ave., San Francisco, CA 94143-0628.
² Department of Radiology, Stanford University Medical Center, 300 Pasteur Dr., Stanford, CA 94305.

View larger version (122K): [in a new window]   Fig. 1A. —55-year-old woman with multiple infiltrating lobular carcinoma lesions. Sagittal three-dimensional water-selective spectral-spatial magnetization transfer MR image shows enhancing tumor clusters (arrows) with nonenhancing intervening tissue.

View larger version (77K): [in a new window]   Fig. 1B. —55-year-old woman with multiple infiltrating lobular carcinoma lesions. Color parametric map of A shows yellow regions that correspond to tumor foci. K21 value maps are used to colorize high-resolution three-dimensional water-selective spectral-spatial magnetization transfer images with colors ranging from cyan (lowest values) to yellow (highest values).

View larger version (159K): [in a new window]   Fig. 1C. —55-year-old woman with multiple infiltrating lobular carcinoma lesions. Photomicrograph shows foci of infiltrating lobular carcinoma (arrows) surrounded by benign breast tissue (B). Normal tissue separates infiltrating lobular carcinoma foci. (H and E, x200)

View larger version (124K): [in a new window]   Fig. 2A. —47-year-old woman with solitary infiltrating lobular carcinoma. Sagittal three-dimensional water-selective spectral-spatial magnetization transfer MR image shows enhancing, solitary, irregular mass (arrow).

View larger version (137K): [in a new window]   Fig. 2B. —47-year-old woman with solitary infiltrating lobular carcinoma. Photomicrograph shows solitary tumor mass (asterisk) with irregular margins. (H and E, x100)

View larger version (126K): [in a new window]   Fig. 3. —69-year-old woman with noncontiguous tumor foci and malignant cells streaming in single-file fashion in breast stroma. Sagittal MR image shows tumor foci (asterisks) connected by enhancing strands (arrows).

View larger version (164K): [in a new window]   Fig. 4A. —43-year-old woman with noncontiguous tumor foci and malignant cells streaming in single-file fashion in breast stroma. Photomicrograph shows tumor focus (arrows) with fibrous strand (S) extending from focus. (H and E, x100)

View larger version (197K): [in a new window]   Fig. 4B. —43-year-old woman with noncontiguous tumor foci and malignant cells streaming in single-file fashion in breast stroma. Photomicrograph of fibrous strand shows classic histologic pattern of tumor cells in single-file arrangements. (H and E, x300)

View larger version (159K): [in a new window]   Fig. 5. —84-year-old woman with tumor cells streaming in breast stroma. Sagittal MR image shows enhancing septa (arrows) with no dominant focus of tumor.

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