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Evaluation of Software for Registration of Contrast-Enhanced Brain MR Images in Patients with Glioblastoma Multiforme

Daniel P. Barboriak1 and James M. Provenzale

1 Both authors: Department of Radiology, Box 3808, Duke University Medical Center, Durham, NC 27710.



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Fig. 1A. 30-year-old man with glioblastoma multiforme. Before image registration, detail of screen capture from Fusion 1.0.15 software (General Electric Medical Systems, Milwaukee, WI) shows axial reference image (upper left) and reformatted sagittal image (lower left) from first contrast-enhanced inversion recovery prepared three-dimensional (3D) spoiled gradient-recalled acquisition in steady state (SPGR) sequence and axial source image (upper right) and reformatted sagittal image (lower right) from second contrast-enhanced inversion recovery prepared 3D SPGR sequence.

 


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Fig. 1B. 30-year-old man with glioblastoma multiforme. After image registration, detail of screen capture from Fusion 1.0.15 software shows axial reference image (upper left) and reformatted sagittal image (lower left) from first contrast-enhanced inversion recovery prepared 3D SPGR sequence and aligned reformatted axial (upper right) and sagittal (lower right) registered images derived from second contrast-enhanced inversion recovery prepared 3D SPGR sequence.

 


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Fig. 2A. 38-year-old man with glioblastoma multiforme. Axial MR image from first contrast-enhanced inversion recovery prepared three-dimensional (3D) spoiled gradient-recalled acquisition in steady state (SPGR) sequence at level of anterior commissure.

 


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Fig. 2B. 38-year-old man with glioblastoma multiforme. Axial MR image from second contrast-enhanced inversion recovery prepared 3D SPGR sequence at same slice location in imaging series as A. Note change in head position, most notably estimated 14.6-mm translation along z-axis.

 


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Fig. 2C. 38-year-old man with glioblastoma multiforme. Reformatted axial image from second contrast-enhanced inversion recovery prepared 3D SPGR sequence registered to A at same slice location as B. Registration was judged satisfactory at visual evaluation.

 


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Fig. 3A. 56-year-old man with glioblastoma multiforme. Axial MR image from first contrast-enhanced inversion recovery prepared three-dimensional (3D) spoiled gradient-recalled acquisition in steady state (SPGR) sequence at level of anterior commissure.

 


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Fig. 3B. 56-year-old man with glioblastoma multiforme. Axial MR image from second contrast-enhanced inversion recovery prepared 3D SPGR sequence at same slice location in imaging series as A. Note change in head position, most notably estimated 20.8° rotation around z-axis (yaw).

 


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Fig. 3C. 56-year-old man with glioblastoma multiforme. Reformatted axial image from second contrast-enhanced inversion recovery prepared 3D SPGR sequence registered to A at same slice location as B. Registration was judged unsatisfactory at visual evaluation.

 


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Fig. 3D. 56-year-old man with glioblastoma multiforme. Reformatted axial MR image from second contrast-enhanced inversion recovery prepared 3D SPGR sequence registered to A at same slice location as B. In this case, second registration was performed to align first registered imaging series (C) to first contrast-enhanced inversion recovery prepared 3D SPGR sequence. Registration was judged satisfactory at visual evaluation.

 

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