Detection of Hepatocellular Carcinoma: Value of Adding Delayed Phase Imaging to Dual-Phase Helical CT
Jae Hoon Lim1,
Dongil Choi1,
Seung Hoon Kim1,
Soon Jin Lee1,
Won Jae Lee1,
Hyo Keun Lim1 and
Seonwoo Kim2
1 Department of Radiology, Samsung Medical Center, 50 Ilwon-dong, Kangnam-ku,
Seoul, Korea 135-710.
2 Biostatistics Unit, Samsung Biomedical Research Institute, Sungkyunkwan
University School of Medicine, Seoul 135-710, Korea.

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Fig. 2A. 71-year-old man with 1.0-cm moderately differentiated
hepatocellular carcinoma in liver segment IV. Arterial phase (A) and
portal venous phase (B) hepatic CT images show no nodular lesions.
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Fig. 2B. 71-year-old man with 1.0-cm moderately differentiated
hepatocellular carcinoma in liver segment IV. Arterial phase (A) and
portal venous phase (B) hepatic CT images show no nodular lesions.
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Fig. 2C. 71-year-old man with 1.0-cm moderately differentiated
hepatocellular carcinoma in liver segment IV. Delayed phase CT image shows
fairly discrete hypoattenuating nodule (arrows).
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Fig. 3A. 66-year-old woman with 1.2-cm well-differentiated
hepatocellular carcinoma in liver segment IV. Arterial phase hepatic CT image
shows no nodular lesion.
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Fig. 3B. 66-year-old woman with 1.2-cm well-differentiated
hepatocellular carcinoma in liver segment IV. On portal venous phase CT image,
subtle lesion (arrows) is hardly seen.
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Fig. 3C. 66-year-old woman with 1.2-cm well-differentiated
hepatocellular carcinoma in liver segment IV. Delayed phase CT image shows
discrete hypoattenuating nodule (arrows).
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Fig. 4A. 62-year-old man with 1.2-cm dysplastic nodule in liver
segment VII. Arterial phase hepatic CT image shows subtle hypoattenuating
nodule (arrows).
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Fig. 4B. 62-year-old man with 1.2-cm dysplastic nodule in liver
segment VII. Portal venous phase (B) and delayed phase (C) CT
images show discrete hypoattenuating nodules (arrows). All observers
interpreted them as possible hepatocellular carcinoma (score, 3).
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Fig. 4C. 62-year-old man with 1.2-cm dysplastic nodule in liver
segment VII. Portal venous phase (B) and delayed phase (C) CT
images show discrete hypoattenuating nodules (arrows). All observers
interpreted them as possible hepatocellular carcinoma (score, 3).
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Fig. 5A. 49-year-old man with 3.8-cm moderately differentiated
hepatocellular carcinoma in liver segment VI. Arterial phase hepatic CT image
shows hyperattenuating nodule (arrows).
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Fig. 5B. 49-year-old man with 3.8-cm moderately differentiated
hepatocellular carcinoma in liver segment VI. On portal venous phase image,
nodule becomes nearly isoattenuating (arrows). This finding is
interpreted as probable hepatocellular carcinoma (score, 5) by all observers
on dual-phase helical CT.
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Fig. 5C. 49-year-old man with 3.8-cm moderately differentiated
hepatocellular carcinoma in liver segment VI. Delayed phase image shows
discrete hypoattenuating nodule with subtle capsular enhancement
(arrows). All observers interpreted nodule as definite hepatocellular
carcinoma (score, 5) on triple-phase helical CT.
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