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Gadolinium-Ethoxybenzyl-Diethylenetriamine Pentaacetic Acid as an Intrabiliary Contrast Agent: Preliminary Assessment

Ruth C. Carlos1, Hero K. Hussain1, Julie H. Song2 and Isaac R. Francis1

1 Department of Radiology, MRI Section, University of Michigan Medical Center, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0300.
2 Department of Diagnostic Imaging, Rhode Island Hospital—Brown University School of Medicine, 593 Eddy St., Providence RI 02912-9706.



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  		Fig. 1A. —62-year-old man with no known biliary disease. Coronal thin-slice reconstruction of three-dimensional T1-weighted spoiled gradient-echo MR cholangiographic data set using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (gadolinium-EOB) depicts more second-order intrahepatic branches (arrows) with increased conspicuity compared with conventional T2-weighted MR cholangiopancreatogram (T2-MRCP, B).

 


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  		Fig. 1B. —62-year-old man with no known biliary disease. Coronal conventional single-shot fast spin-echo T2-MRCP at same level as A is further hampered by slow-flowing veins (arrowhead) appearing as hyperintense structures on T2-weighted images. This limitation was overcome by intrabiliary contrast media. Arrow indicates second-order intrahepatic branch.

 


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  		Fig. 2A. —56-year-old man with no known biliary disease. Oblique coronal thin-slice reconstruction of three-dimensional (3D) T1-weighted spoiled gradient echo MR data set using gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (gadolinium-EOB) depicts right lateral duct (arrowhead) draining into left hepatic duct (solid arrow). Length of right medial duct (open arrow) is better visualized on A than on B. G = gallbladder.

 


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  		Fig. 2B. —56-year-old man with no known biliary disease. Single-shot fast spin-echo conventional MR cholangiopancreatogram obtained in same obliquity as A also shows right lateral duct (arrowhead) draining into left hepatic duct (solid arrow). Length of right medial duct (open arrow) is better visualized on A than on B. G = gallbladder.

 


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  		Fig. 2C. —56-year-old man with no known biliary disease. Forty-millimeter oblique thick-slice reconstruction from 3D gadolinium-EOB—enhanced MR cholangiopancreatogram with small field of view displays right lateral duct (arrowhead) in its entirety.

 


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  		Fig. 3. —Bar graph shows added value of intrabiliary contrast material measured as willingness-to-pay for gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid. Gray bar denotes median value.

 

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