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Invasive Micropapillary Carcinoma of the Breast: Clinical, Mammographic, and Sonographic Findings with Histopathologic Correlation

¹ Department of Radiology, Ege University Hospital, Bornova, 35100, Izmir, Turkey.
² Department of Pathology, Ege University Hospital, Izmir, Turkey.

View larger version (129K): [in a new window]   Fig. 1A. —77-year-old woman who presented for screening. Firm, immobile mass of 2 cm was palpated in upper inner quadrant of right breast at physical examination. Craniocaudal mammogram of right breast shows irregular mass (arrow) of 1.5 cm with spiculated margins.

View larger version (116K): [in a new window]   Fig. 2A. —40-year-old woman with firm mass of 1.5 cm that was palpated in lower outer quadrant of left breast at physical examination. Mediolateral oblique view mammogram of left breast shows pleomorphic and punctate microcalcifications with segmental distribution (arrows) in upper quadrant. Palpable mass is obscured totally in dense breast parenchyma.

View larger version (82K): [in a new window]   Fig. 2B. —40-year-old woman with firm mass of 1.5 cm that was palpated in lower outer quadrant of left breast at physical examination. Sonogram obtained in transverse plane shows ellipsoid, well-circumscribed solid mass of 2 cm (arrows) without capsule and with normal sound transmission in lower outer quadrant of left breast. Histopathologic diagnosis was invasive micropapillary carcinoma, 1.5 cm at largest diameter, in lower outer quadrant of breast and ductal carcinoma in situ in upper outer quadrant.

View larger version (123K): [in a new window]   Fig. 1B. —77-year-old woman who presented for screening. Firm, immobile mass of 2 cm was palpated in upper inner quadrant of right breast at physical examination. Transverse plane sonogram shows round, hypoechoic, solid mass of 1 cm with irregular margins and prominent posterior acoustic shadowing. Histopathologic diagnosis was invasive micropapillary carcinoma, 1.4 cm at largest diameter.

View larger version (159K): [in a new window]   Fig. 1C. —77-year-old woman who presented for screening. Firm, immobile mass of 2 cm was palpated in upper inner quadrant of right breast at physical examination. Photomicrograph of biopsy specimen shows tumor cell nests within fine reticular stroma. (H and E, x100)

View larger version (140K): [in a new window]   Fig. 2C. —40-year-old woman with firm mass of 1.5 cm that was palpated in lower outer quadrant of left breast at physical examination. Photomicrograph of biopsy specimen shows low-power appearance of invasive micropapillary carcinoma of breast with well-defined margins (arrows). (H and E, x40)

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