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Evaluation of Normal Age-Related Changes in Anisotropy During Infancy and Childhood as Shown by Diffusion Tensor Imaging

¹ All authors: Department of Radiology, Duke University Medical Center, Box 3808, Durham, NC 27710.

View larger version (72K): [in a new window]   Fig. 1A. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 1-month-old male infant (group 1) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow, intermediate anisotropy values are depicted in green, and lowest anisotropy values are depicted in blue. ROIs placed in corona radiata have mean anisotropy measurement of 0.282 in this structure.

View larger version (63K): [in a new window]   Fig. 1B. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 1-month-old male infant (group 1) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow, intermediate anisotropy values are depicted in green, and lowest anisotropy values are depicted in blue. ROIs placed in posterior limb of both internal capsules show mean anisotropy measurement of 0.454 in this structure.

View larger version (63K): [in a new window]   Fig. 1C. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 1-month-old male infant (group 1) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow, intermediate anisotropy values are depicted in green, and lowest anisotropy values are depicted in blue. ROIs placed in cerebral peduncle show mean anisotropy measurement of 0.274.

View larger version (46K): [in a new window]   Fig. 2A. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 27-month-old boy (group 2) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow. Note the increase in anisotropy in these color-coded maps (i.e., increase in size of red and yellow regions) compared with images shown in Figure 1A,1B,1C. ROIs placed in corona radiata have mean anisotropy measurement of 0.414 in this structure.

View larger version (50K): [in a new window]   Fig. 2B. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 27-month-old boy (group 2) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow. Note the increase in anisotropy in these color-coded maps (i.e., increase in size of red and yellow regions) compared with images shown in Figure 1A,1B,1C. ROIs placed in posterior limb of both internal capsules show mean anisotropy measurement of 0.654 in this structure.

View larger version (51K): [in a new window]   Fig. 2C. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 27-month-old boy (group 2) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow. Note the increase in anisotropy in these color-coded maps (i.e., increase in size of red and yellow regions) compared with images shown in Figure 1A,1B,1C. ROIs placed in cerebral peduncle show mean anisotropy measurement of 0.625.

View larger version (47K): [in a new window]   Fig. 3A. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 61-month-old girl (group 3) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow. ROIs placed in corona radiata have mean anisotropy measurement of 0.475 in this structure.

View larger version (45K): [in a new window]   Fig. 3B. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 61-month-old girl (group 3) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow. ROIs placed in posterior limb of both internal capsules show mean anisotropy measurement of 0.752 in this structure.

View larger version (59K): [in a new window]   Fig. 3C. —Color-coded anisotropy maps show placement of regions of interest (ROIs) in 61-month-old girl (group 3) in whom no brain abnormalities were detected on clinical MR imaging. Highest anisotropy values are depicted in red and yellow. ROIs placed in cerebral peduncle show mean anisotropy measurement of 0.685.

View larger version (17K): [in a new window]   Fig. 4. —Graph shows mean anisotropy values increase across group 1 (<12 months old), group 2 (12-35 months old), and group 3 (36-71 months old) for each of the five white matter structures measured. Compact white matter structures are depicted in red (square, corpus callosum; circle, internal capsule; triangle, cerebral peduncle). Noncompact white matter structures are depicted in blue (square, frontal—parietal lobe; diamond, corona radiata).

View larger version (18K): [in a new window]   Fig. 5. —Bar graph shows mean anisotropy values within noncompact white matter structures (blue) and compact white matter structures (red) in group 1 (<12 months old), group 2 (12-35 months old), and group 3 (36-71 months old).

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