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Gadobenate Dimeglumine—Enhanced MR Angiography of the Abdominal Aorta and Renal Arteries

Thomas J. Kroencke1, Martin N. Wasser2, Peter M. T. Pattynama3, Jelle O. Barentsz4, Eckhardt Grabbe5, Guy Marchal6, Michael V. Knopp7, Günther Schneider8, Lorenzo Bonomo9, Dudley J. Pennell10, Alessandro Del Maschio11, Hans-Rainer Hentrich12, Massimo Daprà13, Miles A. Kirchin13, Alberto Spinazzi13, Matthias Taupitz1 and Bernd Hamm1

1 Department of Radiology, Universitätsklinikum Charité, Medizinische Fakultät, Humboldt-Universität zu Berlin, Schumannstr. 20/21, 10098 Berlin, Germany.
2 Department of Radiology, Leiden University Medical Center, Albinusdreef 2, 2333 AA Leiden, The Netherlands.
3 Department of Radiology, Erasmus University Medical Center Rotterdam, 40, Doctor Molewaterplein, NL 3015 GD Rotterdam, The Netherlands.
4 Department of Radiology, University Hospital Nijmegen—St. Radboud, 6500 HB Nijmegen, The Netherlands.
5 Abt. Röntgendiagnostik I, Klinikum der Georg-August-Universität, Robert-Koch-Str. 40, D-37075 Göttingen, Germany.
6 Department of Radiology, University Hospital Leuven, Herestr. 49, 3000 Leuven, Belgium.
7 Department of Radiology, German Cancer Research Center, Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
8 Department of Diagnostic Radiology, University Hospital, 66421 Homburg/Saar, Germany.
9 Instituto di Scienze Radiologiche e Formazione dell'Immagine, Ospedale SS. Annunziata, Via P Valignani 66100, Chieti, Italy.
10 Magnetic Resonance Unit, Royal Brompton Hospital, Sidney St., London SW3 6NP, United Kingdom.
11 Department of Radiology, Scientific Institute S. Raffaele, University Hospital, Milan, Italy.
12 Bracco-Byk Gulden, Max Stromeyer Str., 57, 78467 Konstanz, Germany.
13 Worldwide Medical Affairs, Bracco Imaging SpA, Via E. Folli, 50, 20134, Milano, Italy.



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  		Fig. 1. —Graph shows adjusted mean change (with 95% confidence intervals) in total diagnostic quality score from unenhanced time-of-flight MR angiography to contrast-enhanced MR angiography with gadobenate dimeglumine. Note that greatest mean increase in total diagnostic quality score was observed for gadobenate dimeglumine dose of 0.1 mmol/kg of body weight. {diamondsuit} = off-site reviewer 1, {blacksquare} = off-site reviewer 2, {blacktriangleup} = on-site principal investigators.

 


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  		Fig. 2A. —49-year-old woman (weight, 56 kg) with high-grade stenosis of infrarenal aorta who received 3 mL (0.025 mmol/kg) of gadobenate dimeglumine. Contrast-enhanced MR angiogram reveals severe atherosclerotic plaque formation with high-grade stenosis (arrow) of infrarenal aorta.

 


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  		Fig. 2B. —49-year-old woman (weight, 56 kg) with high-grade stenosis of infrarenal aorta who received 3 mL (0.025 mmol/kg) of gadobenate dimeglumine. Digital subtraction angiogram reveals lesion seen in A (arrow). Note lack of clarity on this image compared with contrast-enhanced MR angiogram obtained with gadobenate dimeglumine.

 


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  		Fig. 3A. —77-year-old woman (weight, 69 kg) with severe eccentric stenosis of left renal artery who received 7 mL (0.05 mmol/kg) of gadobenate dimeglumine. Contrast-enhanced MR angiogram reveals severe eccentric stenosis (arrow) of left renal artery.

 


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  		Fig. 3B. —77-year-old woman (weight, 69 kg) with severe eccentric stenosis of left renal artery who received 7 mL (0.05 mmol/kg) of gadobenate dimeglumine. Digital subtraction angiogram reveals lesion seen in A (arrow). Note excellent correlation between contrast-enhanced MR angiography with gadobenate dimeglumine and digital subtraction angiography.

 


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  		Fig. 4. —28-year-old man (weight, 66 kg) with no obvious vascular abnormality who received 13 mL (0.1 mmol/kg) of gadobenate dimeglumine. Contrast-enhanced MR angiogram reveals strong enhancement of abdominal aorta, main renal arteries, and splanchnic vessels. Note good visibility of jejunal branches (arrows) of superior mesenteric artery.

 


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  		Fig. 5. —63-year-old woman (weight, 58 kg) with no obvious vascular abnormality who received 23 mL (0.2 mmol/kg) of gadobenate dimeglumine. Contrast-enhanced MR angiogram reveals normal anatomy of vessels of upper abdomen and detailed depiction of celiac trunk and superior mesenteric artery. Note that even renal vessels in hilum can be evaluated well.

 

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