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Efficacy of Computerized Infrared Imaging Analysis to Evaluate Mammographically Suspicious Lesions

Y. R. Parisky1, A. Sardi2, R. Hamm3, K. Hughes4, L. Esserman5, S. Rust6 and K. Callahan7

1 USC/Norris Cancer Center, 1441 Eastlake Ave., Los Angeles, CA 90033.
2 St. Agnes Healthcare, 900 Caton Ave. S., Baltimore, MD 21229.
3 Providence Hospital, 1150 Varnum St., N.E., Washington, DC 20017.
4 Lahey Clinic Northshore, One Essex Center Dr., Peabody, MA 01960.
5 Mt. Sinai Medical Center, 4306 Alton Rd., Miami, FL 33140.
6 Battelle, 505 King Ave., Columbus, OH 43201.
7 Computerized Thermal Imaging, Two Centerpointe Dr., Ste. 450, Lake Oswego, OR 97035.



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  		Fig. 1A. —67-year-old woman with 2.5-cm asymmetric density in left breast at 3-o'clock position. Note that regions of interest were placed at 3-o'clock position by two of three evaluating radiologists. Lateral (A) and craniocaudal (B) mammograms show suspicious lesion.

 


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  		Fig. 1B. —67-year-old woman with 2.5-cm asymmetric density in left breast at 3-o'clock position. Note that regions of interest were placed at 3-o'clock position by two of three evaluating radiologists. Lateral (A) and craniocaudal (B) mammograms show suspicious lesion.

 


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  		Fig. 1C. —67-year-old woman with 2.5-cm asymmetric density in left breast at 3-o'clock position. Note that regions of interest were placed at 3-o'clock position by two of three evaluating radiologists. Infrared image shows en face view of each breast. On perimeter are six side-mirror images of each breast. Breast tissue is outlined in red, and regions of interest are outlined in yellow.

 


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  		Fig. 2. —Graph shows relationship of specificity to breast density. Density of breast tissue was categorized by evaluating radiologists using mammograms during infrared image assessment. Of 875 lesions evaluated, 55 were found in almost entirely fat breast tissue (sensitivity = 100%); 315 lesions, in scattered fibroglandular breast tissue (sensitivity = 94%); 395 lesions, in heterogeneously dense breast tissue (sensitivity = 98%); 110 lesions, in extremely dense breast tissue (sensitivity = 100%).

 


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  		Fig. 3. —Scatterplot shows relationship of lesion size to infrared signal in malignant masses. Note that as lesion size increases, infrared index-of-suspicion score also increases.

 

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