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Interobserver Reproducibility of Volumetric MR Imaging Measurements of Plexiform Neurofibromas

Tina Young Poussaint1, Diego Jaramillo2, Yuchiao Chang3 and Bruce Korf4

1 Department of Radiology, Children's Hospital and Harvard Medical School, 300 Longwood Ave., Boston, MA 02115.
2 Department of Radiology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit St., Boston, MA 02114.
3 Department of Medicine, Massachusetts General Hospital and Harvard Medical School, 50 Staniford St., 9th Floor, Boston, MA 02114.
4 Harvard—Partners Center for Genetics and Genomics and Harvard Medical School, 77 Ave. Louis Pasteur, Boston, MA 02115.



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  		Fig. 1. —Graph illustrates variation in volumetric measurements from mean among three observers. Volumes are graphed on logarithmic scale to show better variability by average volume. Most variation is less than 5% of mean volume. {circ} = radiologist 1, {square} = radiologist 2, {triangleup} = technologist.

 


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  		Fig. 2. —15-year-old girl with neurofibromatosis 1 and scalp mass. Axial fast spinecho inversion recovery MR image shows lobulated scalp plexiform neurofibroma involving right temporalis muscle and suboccipital soft tissues. Volumetric measurements are outlined in red.

 


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  		Fig. 3. —9-year-old girl with neurofibromatosis 1 and arm pain. Axial fast spin-echo inversion recovery MR image shows right brachial plexus lesion at level of lower cervical spine. Volumetric measurements are outlined in red.

 


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  		Fig. 4. —47-year-old woman with neurofibromatosis 1 and buttock mass. Axial fast spin-echo inversion recovery MR image obtained with patient in prone position shows large lesion involving subcutaneous tissues of gluteal region. Volumetric measurements are outlined in red.

 

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