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Thymic Enlargement and FDG Uptake in Three Patients: CT and FDG Positron Emission Tomography Correlated with Pathology

Conrad Wittram1, Allan J. Fischman1, Eugene Mark2, Jane Ko3 and Jo-Anne O. Shepard1

1 Department of Radiology, Massachusetts General Hospital and Harvard University, 55 Fruit St., Boston, MA 02114.
2 Department of Pathology, Massachusetts General Hospital and Harvard University, Boston, MA 02114.
3 Department of Radiology, Thoracic Imaging, New York University, 560 1st Ave., New York, NY 10016.



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  		Fig. 1A. —Thymic enlargement in 29-year-old woman. Contrast-enhanced CT scan of thorax obtained at level of left brachiocephalic vein shows soft tissue (arrow) among left brachiocephalic vein anteriorly, superior vena cava laterally, and right brachiocephalic artery and left common carotid artery posteriorly.

 


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  		Fig. 1B. —Thymic enlargement in 29-year-old woman. Axial FDG positron emission tomography (PET) scan obtained at same level as A shows increase in uptake of FDG in soft tissue (arrows) compared with mediastinum.

 


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  		Fig. 1C. —Thymic enlargement in 29-year-old woman. Contrast-enhanced CT scan obtained at level of aortic arch shows thickness of thymus to be 1.5 cm. Note convex lateral margin.

 


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  		Fig. 1D. —Thymic enlargement in 29-year-old woman. Axial FDG PET scan obtained at same level as C shows increase in uptake of FDG in thymus (arrow).

 


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  		Fig. 2A. —Thymic enlargement in 44-year-old woman with history of malignant melanoma. Contrast-enhanced CT scan of thorax obtained at level of carina shows soft tissue in region of thymus. Left lobe of thymus measures 1.7 cm in thickness and has slight convex lateral margin.

 


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  		Fig. 2B. —Thymic enlargement in 44-year-old woman with history of malignant melanoma. Axial FDG positron emission tomography scan obtained at same level as A shows increase in uptake of FDG in thymus (arrows).

 


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  		Fig. 3A. —Thymic enlargement in 32-year-old woman with history of breast cancer. Contrast-enhanced CT scan of thorax obtained at level of aortic arch shows soft tissue in region of thymus. Left and right lobes of thymus measure 2.1 cm and 1 cm in thickness, respectively, and have convex lateral margins. Note left breast mass.

 


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  		Fig. 3B. —Thymic enlargement in 32-year-old woman with history of breast cancer. Axial FDG positron emission tomography scan shows increase in uptake of FDG in thymus.

 

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