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Serial MR Imaging of Volumes of Hyperintense White Matter Lesions in Elderly Patients: Correlation with Vascular Risk Factors

Warren D. Taylor1, James R. MacFall2, James M. Provenzale2, Martha E. Payne1, Douglas R. McQuoid1, David C. Steffens1 and K. Ranga Rama Krishnan1

1 Department of Psychiatry, Duke University Medical Center, DUMC 3903, Durham, NC 27710.
2 Department of Radiology, Duke University Medical Center, DUMC 3808, Durham, NC 27710.



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  		Fig. 1A. —73-year-old woman with normal cognition who reported diagnosis of diabetes. Proton density–weighted axial MR image (TR/TE, 4000/30) shows multiple hyperintense foci scattered throughout centrum semiovale.

 


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  		Fig. 1B. —73-year-old woman with normal cognition who reported diagnosis of diabetes. Volumetric segmentation image obtained from A shows hyperintense foci (red), cerebrospinal fluid (blue), white matter (yellow), and gray matter (gray). Cerebral hyperintense white matter lesion volume is 7.00 cm2.

 


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  		Fig. 1C. —73-year-old woman with normal cognition who reported diagnosis of diabetes. Proton density–weighted image obtained approximately 23 months after A shows substantial change in number of hyperintense lesions. No change in clinical status was noted.

 


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  		Fig. 1D. —73-year-old woman with normal cognition who reported diagnosis of diabetes. Volumetric segmentation image obtained from C shows cerebral hyperintense white matter lesions with volume of 11.60 cm2 or volume increase of 65.7%.

 

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