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Improvement in Sensitivity of Screening Mammography with Computer-Aided Detection: A Multiinstitutional Trial

Rachel F. Brem1, Janet Baum2, Mary Lechner3, Stuart Kaplan4, Stuart Souders5, L. Gill Naul6 and Jeff Hoffmeister7

1 Department of Breast Imaging and Intervention, George Washington University Medical Center, 2150 Pennsylvania Ave. N.W., Washington, DC 20037.
2 Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Ave., CC0492, Boston, MA 02215.
3 Jane Brattain Breast Center, Park-Nicollett Clinic, St. Louis Park, MN 55416.
4 Strax Institute, 4300 N. University Dr., Lauderhill, FL 33332.
5 Department of Radiology, Kaiser Permanente Medical Center, 9961 Sierra Ave., Fontana, CA 92335.
6 Department of Radiology, Scott and White Clinic, 2401 S. 31st St., Temple, TX 76508.
7 CADx Systems, Ste. 100, 2689 Commons Blvd., Beavercreek, OH 45431.



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  		Fig. 1. —Flowchart of study cases shows cases of potentially missed breast cancer, workup recommended, and missed cancers.

 


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  		Fig. 2A. —Printouts of digitized mammograms in 56-year-old woman who underwent screening mammography for breast cancer. Printouts were generated by computer-aided detection software (Second Look [version 3.4], CADx Systems, Beavercreek, OH). Printouts of craniocaudal (A) and mediolateral oblique (B) views highlight areas with suspicious findings. Ellipses mark potential masses (nonspiculated masses, spiculated masses, architectural distortions, and asymmetric densities), and rectangles mark potential microcalcifications.

 


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  		Fig. 2B. —Printouts of digitized mammograms in 56-year-old woman who underwent screening mammography for breast cancer. Printouts were generated by computer-aided detection software (Second Look [version 3.4], CADx Systems, Beavercreek, OH). Printouts of craniocaudal (A) and mediolateral oblique (B) views highlight areas with suspicious findings. Ellipses mark potential masses (nonspiculated masses, spiculated masses, architectural distortions, and asymmetric densities), and rectangles mark potential microcalcifications.

 

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